Document Detail

Effect of ertapenem protein binding on killing of bacteria.
MedLine Citation:
PMID:  15328106     Owner:  NLM     Status:  MEDLINE    
The effect of protein binding on the antimicrobial activity of ertapenem was evaluated using the bacterial kill rate and concentration-response studies. Various proportions of human serum were utilized to determine the total and free-drug concentrations using a validated high-performance liquid chromatography assay. The MICs and kill curves were determined for test isolates of Enterobacter cloacae and Staphylococcus aureus at various percentages of human serum. The killing of bacteria was analyzed in relation to the free and total concentrations of ertapenem at various proportions of human serum. It was determined that unbound ertapenem was responsible for the antimicrobial activity against the test isolates.
David E Nix; Kathryn R Matthias; Emily C Ferguson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  48     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-25     Completed Date:  2004-10-18     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3419-24     Citation Subset:  IM    
Department of Pharmacy Practice and Science, College of Pharmacy, University of Arizona, 1703 E. Mabel St., P.O. Box 210-207, Tucson, AZ 85721-0207, USA.
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MeSH Terms
Bacteria / drug effects*
Chromatography, High Pressure Liquid
Enterobacter cloacae / drug effects
Enterobacteriaceae Infections / microbiology
Indicators and Reagents
Lactams / metabolism*,  pharmacology*
Microbial Sensitivity Tests
Protein Binding
Regression Analysis
Spectrophotometry, Ultraviolet
Staphylococcal Infections / microbiology
Staphylococcus aureus / drug effects
Reg. No./Substance:
0/Indicators and Reagents; 0/Lactams; 0/beta-Lactams; G32F6EID2H/ertapenem

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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