Document Detail


Effect of ergothioneine on acute lung injury and inflammation in cytokine insufflated rats.
MedLine Citation:
PMID:  22197759     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The Acute Respiratory Distress Syndrome (ARDS), the most severe form of Acute Lung Injury (ALI), is a highly-fatal, diffuse non-cardiogenic edematous lung disorder. The pathogenesis of ARDS is unknown but lung inflammation and lung oxidative stress are likely contributing factors. Since no specific pharmacologic intervention exists for ARDS, our objective was to determine the effect of treatment with ergothioneine-a safe agent with multiple anti-inflammatory and antioxidant properties on the development of lung injury and inflammation in rats insufflated with cytokines found in lung lavages of ARDS patients.
METHOD: Sprague-Dawley rats (3-10/group) were given 15 mg/kg or 150 mg/kg l-ergothioneine intravenously 1h before or 18 h after cytokine (IL-1 and IFNγ) insufflation. Lung injury (lavage LDH levels) and lung inflammation (lavage neutrophil numbers) were measured 24h after cytokine insufflation.
RESULTS: Ergothioneine pre- and post-treatment generally decreased lung injury and lung inflammation in cytokine insufflated rats.
CONCLUSION: Ergothioneine should be considered for additional testing as a potential therapy for treating and preventing ARDS.
Authors:
John E Repine; Nancy D Elkins
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2011-12-14
Journal Detail:
Title:  Preventive medicine     Volume:  54 Suppl     ISSN:  1096-0260     ISO Abbreviation:  Prev Med     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-14     Completed Date:  2012-09-28     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  0322116     Medline TA:  Prev Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S79-82     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Webb-Waring Center, University of Colorado Denver, V20, Mail Stop C322, 12850 East Montview Blvd., Aurora, CO 80045, USA. john.repine@ucdenver.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / administration & dosage,  pharmacology*
Cytokines / administration & dosage*,  metabolism
Ergothioneine / administration & dosage,  pharmacology*
Male
Pneumonia / drug therapy*
Rats
Rats, Sprague-Dawley
Respiratory Distress Syndrome, Adult / drug therapy*,  physiopathology
Grant Support
ID/Acronym/Agency:
R01 HL045582-16/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Cytokines; 497-30-3/Ergothioneine
Comments/Corrections

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