Document Detail

Effect of epinephrine on the oxidative desaturation of fatty acids in the rat adrenal gland.
MedLine Citation:
PMID:  3736349     Owner:  NLM     Status:  MEDLINE    
Delta-6 and delta 5 desaturation activity of rat adrenal gland microsomes was studied to determine the effect of microsomal protein and the substrate saturation curves. This tissue has a very active delta 6 desaturase for linoleic and alpha-linolenic acids. The administration of epinephrine (1 mg/kg body weight) 12 hr before killing, produced approximately a 50% decrease in desaturation of [1-14C]linoleic acid to gamma-linolenic acid, [1-14C]alpha-linolenic acid to octadeca-6,9,12,15-tetraenoic acid and [1-14C]eicosa-8,11,14-trienoic acid to arachidonic acid. A 30% decrease in delta 5 desaturation activity was also shown after 7 hr of epinephrine treatment. The changes on the oxidative desaturation of the same fatty acids in liver microsomes were similar. No changes were observed in the total fatty acid composition of adrenal microsomes 12 hr after epinephrine treatment. Mechanisms of action of the hormone on the biosynthesis of polyunsaturated fatty acids in the adrenal gland are discussed.
E C Mandon; I N de Gomez Dumm; R R Brenner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lipids     Volume:  21     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-09-17     Completed Date:  1986-09-17     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  401-4     Citation Subset:  IM    
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MeSH Terms
Adrenal Glands / drug effects,  enzymology*
Carbon Radioisotopes
Epinephrine / pharmacology*
Fatty Acid Desaturases / metabolism*
Fatty Acids, Nonesterified / metabolism*
Microsomes / drug effects,  enzymology*
Rats, Inbred Strains
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Fatty Acids, Nonesterified; 51-43-4/Epinephrine; EC 1.14.19.-/Fatty Acid Desaturases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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