| Effect of epidural and intravenous use of the neurokinin-1 (NK-1) receptor antagonist maropitant on the sevoflurane minimum alveolar concentration (MAC) in dogs. | |
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MedLine Citation:
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PMID: 22103569 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective To determine the effect of maropitant, an NK-1 receptor antagonist on the minimum alveolar concentration (MAC) of sevoflurane after intravenous and epidural administration to dogs. Study design Prospective experimental study. Animals Seven, adult, spayed-female dogs (24.8 ± 1.9 kg). Methods Each dog was anesthetized twice with sevoflurane in oxygen, with at least 10 days separating the anesthetic events. The minimum alveolar concentration (MAC) of sevoflurane was determined using the tail-clamp technique. During the first anesthetic event, the MAC of sevoflurane was determined initially and again after intravenous administration of maropitant (5 mg kg(-1) ) and an infusion (150 μg kg(-1) hour(-1) ). During the second anesthetic event, an epidural catheter was advanced to the 4th lumbar vertebra and MAC was determined after administration of saline and maropitant (1 mg kg(-1) ) epidurally. All MAC determinations were done in duplicate. The MAC values were adjusted to sea level and compared using student's t-test. Results The baseline MAC for sevoflurane was 2.08 ± 0.25%. Intravenous maropitant decreased (p < 0.05) MAC by 16% (1.74 ± 0.17%). In contrast, epidural administration of either saline or maropitant did not change (p > 0.05) the MAC (2.17 ± 0.34% and 1.92 ± 0.12%, respectively). Conclusion and clinical relevance Maropitant decreased the MAC of sevoflurane when administered intravenously to dogs but not after epidural administration. |
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Authors:
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Brittany M Alvillar; Pedro Boscan; Khursheed R Mama; Tatiana H Ferreira; Jonathan Congdon; David C Twedt |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-22 |
Journal Detail:
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Title: Veterinary anaesthesia and analgesia Volume: - ISSN: 1467-2995 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100956422 Medline TA: Vet Anaesth Analg Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Authors. Veterinary Anaesthesia and Analgesia. © 2011 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesiologists. |
Affiliation:
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College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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