| Effect of enzymatic hydrolysis on cholesterol-lowering activity of oat beta-glucan. | |
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MedLine Citation:
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PMID: 19931657 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, oat beta-glucan hydrolysate, having average molecular weight of 730,000g/mol which was previously shown to have great in vitro bile acid binding capacity, was prepared by enzymatic hydrolysis. Furthermore its in vivo hypocholestrolemic effects were evaluated in rats that were fed high-cholesterol diets. Supplements with beta-glucan hydrolysate as well as native beta-glucan significantly reduced the levels of LDL- and VLDL-cholesterol in serum and further improved the lipid profile in liver. When rats were fed high-cholesterol diets, supplemented with the beta-glucan hydrolysate, greater fecal bile acid excretion was observed, which could be favorably correlated to in vitro bile acid binding capacity. In addition, the hydrolysate was more effective at increasing the excretion of fecal cholesterol and triglyceride than the native beta-glucan, showing its effectiveness in improving the lipid profile. |
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Authors:
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In Young Bae; Sung Mi Kim; Suyong Lee; Hyeon Gyu Lee |
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Publication Detail:
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Type: Journal Article Date: 2009-11-26 |
Journal Detail:
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Title: New biotechnology Volume: 27 ISSN: 1876-4347 ISO Abbreviation: N Biotechnol Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-03-01 Completed Date: 2010-05-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101465345 Medline TA: N Biotechnol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 85-8 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Food and Nutrition, Hanyang University, Seoul, 133-791, Republic of Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticholesteremic Agents / metabolism* Avena sativa / chemistry* Bile Acids and Salts / metabolism Cholesterol, Dietary / metabolism* Cholesterol, LDL / metabolism Cholesterol, VLDL / metabolism Diet* Feces / chemistry Hydrolysis Lipids / blood Liver / chemistry Molecular Weight Rats beta-Glucans / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Bile Acids and Salts; 0/Cholesterol, Dietary; 0/Cholesterol, LDL; 0/Cholesterol, VLDL; 0/Lipids; 0/beta-Glucans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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