Document Detail

Effect of enteral feeding on the maintenance of gastric acid secretory function.
MedLine Citation:
PMID:  6401255     Owner:  NLM     Status:  MEDLINE    
The effects of enteral feeding on the maintenance of gastrointestinal function in human infants are unknown. The effects of enteral feeding on gastric acid secretory function were studied by investigating three groups of infants: infants fed normally, infants with gastrointestinal disease fed by a combination of enteral and parenteral means, and infants fed by total parenteral nutrition. In 14 infants with gastrointestinal disease fed with total parenteral nutrition for a mean of 7 mo (range 1.5-24 mo), basal gastric acid secretion and pentagastrin-stimulated maximal gastric acid secretion were significantly less than in 26 normal infants (p less than 0.01) and in 11 infants with gastrointestinal disease nourished with a combination of enteral and parenteral feeding (p less than 0.01). In each of seven infants fed with total parenteral nutrition for a mean of 5 mo (range 1.5-10 mo), basal and maximal gastric acid secretion increased after a 6-8-wk trial of enteral feeding, a highly significant difference. In one infant, the ability to secrete normal amounts of acid in response to pentagastrin (achieved after an initial trial of enteral feeding) was lost after a 4-mo enteral fast, but returned after a second trial of enteral feeding. These results demonstrate that, in human infants, enteral feedings are necessary for normal oxyntic mucosal secretory function.
P E Hyman; E J Feldman; M E Ament; W J Byrne; A R Euler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gastroenterology     Volume:  84     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-02-25     Completed Date:  1983-02-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  341-5     Citation Subset:  AIM; IM    
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MeSH Terms
Child, Preschool
Enteral Nutrition*
Gastric Acid / secretion*
Gastric Mucosa / secretion
Gastrointestinal Diseases / physiopathology,  therapy
Infant, Newborn
Parenteral Nutrition*
Parenteral Nutrition, Total*
Pentagastrin / diagnostic use
Stimulation, Chemical
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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