Document Detail


Effect of enhancers and retarders on percutaneous absorption of flurbiprofen from hydrogels.
MedLine Citation:
PMID:  12527159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of enhancers/retarders on the transdermal absorption of flurbiprofen from cellulose hydrogels was studied in vitro. The release rate of flurbiprofen and the viscosity of hydrogel matrices were also examined. The flux of flurbiprofen from cellulose hydrogels approximated that from aqueous buffers, whereas the skin reservoir of flurbiprofen was lower with hydrogels. Incorporation of the cosolvents, propylene glycol (PG) and ethanol, did not significantly increase skin absorption of flurbiprofen. Ethanol even reduced the skin reservoir of the drug. Oleic acid, an unsaturated fatty acid, produced the largest skin reservoir of the drug when incorporated into the hydrogels. D-Limonene, a cyclic monoterpene, showed the greatest ability to enhance the flux of flurbiprofen. However, phospholipids as retarders markedly reduced the skin absorption of flurbiprofen. The mechanisms by which enhancers/retarders govern flurbiprofen permeation were elucidated by in vitro permeation studies using various skin types (enhancers/retarders-pretreated skin, stratum corneum (SC)-stripped skin, and delipidized skin) and histological examination. The results suggest different mechanisms and skin structural modifications caused by different enhancers/retarders.
Authors:
Jia-You Fang; Tsong-Long Hwang; Yann-Lii Leu
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  250     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-01-15     Completed Date:  2003-07-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  313-25     Citation Subset:  IM    
Affiliation:
Graduate Institute of Natural Products, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, Taiwan. fajy@mail.cgu.edu.tw
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Animals
Chemistry, Pharmaceutical
Female
Flurbiprofen / administration & dosage,  pharmacokinetics*
Hydrogels / administration & dosage,  pharmacokinetics*
Mice
Mice, Inbred BALB C
Mice, Nude
Skin Absorption / drug effects*,  physiology
Chemical
Reg. No./Substance:
0/Hydrogels; 5104-49-4/Flurbiprofen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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