Document Detail

Effect of energy deprivation on the polyribosomes of Yoshida ascites hepatoma cells.
MedLine Citation:
PMID:  6616429     Owner:  NLM     Status:  MEDLINE    
Yoshida ascites hepatoma cells growing in vivo are characterized by a large number of monosomes and dimers which further increase when the cells are incubated anaerobically in vitro in the absence of glucose: under the latter condition most of the ribosomes are present as inactive particles. These monosomes can be incorporated into polyribosomes if the elongation step of protein synthesis is inhibited by cycloheximide. The degradation of polysomes in the absence of glucose under anaerobic conditions can be reversed promptly on addition of glucose to the medium and less promptly by oxygenation. These data suggest that the large monosome-dimer pool of hepatoma cells depends on a relative inefficiency of the initiation step of protein synthesis, which is magnified by the lack of energy caused by anaerobic incubation in the absence of glucose, and counteracted by interference with further steps of protein synthesis or conditions which favor glycolysis or, less efficiently, respiration of the tumor cells.
M E Ferrero; A Bernelli-Zazzera
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer biochemistry biophysics     Volume:  6     ISSN:  0305-7232     ISO Abbreviation:  Cancer Biochem. Biophys.     Publication Date:  1983  
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7506524     Medline TA:  Cancer Biochem Biophys     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  229-36     Citation Subset:  IM    
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MeSH Terms
Cycloheximide / pharmacology
Energy Metabolism
Glucose / metabolism
Liver Neoplasms, Experimental / metabolism*
Molecular Weight
Peptide Chain Initiation, Translational
Polyribosomes / drug effects,  metabolism*
Reg. No./Substance:
50-99-7/Glucose; 66-81-9/Cycloheximide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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