Document Detail


Effect of endurance training on lipid metabolism in women: a potential role for PPARalpha in the metabolic response to training.
MedLine Citation:
PMID:  10913035     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Endurance training increases fatty acid oxidation (FAO) and skeletal muscle oxidative capacity. However, the source of the additional fat and the mechanisms for increasing FAO capacity in muscle are not clear. We measured whole body and regional lipolytic activity and whole body and plasma FAO in six lean women during 90 min of bicycling exercise (50% pretraining peak O(2) consumption) before and after 12 wk of endurance training. We also assessed skeletal muscle content of peroxisome proliferator-activated receptor-alpha (PPARalpha) and its target proteins that regulate FAO [medium-chain and very long chain acyl-CoA dehydrogenase (MCAD and VLCAD)]. Despite a 25% increase in whole body FAO during exercise after training (P < 0.05), training did not alter regional adipose tissue lipolysis (abdominal: 0.56 +/- 0.26 and 0.57 +/- 0.10 micromol x 100 g(-1) x min(-1); femoral: 0.13 +/- 0.07 and 0.09 +/- 0.02 micromol x 100 g(-1) x min(-1)), whole body palmitate rate of appearance in plasma (168 +/- 18 and 150 +/- 25 micromol/min), and plasma FAO (554 +/- 61 and 601 +/- 45 micromol/min). However, training doubled the levels of muscle PPARalpha, MCAD, and VLCAD. We conclude that training increases the use of nonplasma fatty acids and may enhance skeletal muscle oxidative capacity by PPARalpha regulation of gene expression.
Authors:
J F Horowitz; T C Leone; W Feng; D P Kelly; S Klein
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of physiology. Endocrinology and metabolism     Volume:  279     ISSN:  0193-1849     ISO Abbreviation:  Am. J. Physiol. Endocrinol. Metab.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-08-31     Completed Date:  2000-08-31     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100901226     Medline TA:  Am J Physiol Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E348-55     Citation Subset:  IM; S    
Affiliation:
Department of Internal Medicine and Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
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MeSH Terms
Descriptor/Qualifier:
Acyl-CoA Dehydrogenase
Acyl-CoA Dehydrogenase, Long-Chain / metabolism
Adipose Tissue / metabolism
Adult
Citrate (si)-Synthase / metabolism
Epinephrine / blood
Fatty Acids / blood
Female
Glycerol / blood
Humans
Insulin / blood
Lipid Metabolism*
Lipolysis / physiology
Muscle, Skeletal / metabolism
Norepinephrine / blood
Oxidation-Reduction
Physical Endurance / physiology*
Physical Exertion / physiology*
Receptors, Cytoplasmic and Nuclear / metabolism*
Transcription Factors / metabolism*
Grant Support
ID/Acronym/Agency:
DK-09749-01A1/DK/NIDDK NIH HHS; DK-37948/DK/NIDDK NIH HHS; DK-45416/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Receptors, Cytoplasmic and Nuclear; 0/Transcription Factors; 11061-68-0/Insulin; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 56-81-5/Glycerol; EC 1.3.99.13/Acyl-CoA Dehydrogenase, Long-Chain; EC 1.3.99.3/Acyl-CoA Dehydrogenase; EC 2.3.3.1/Citrate (si)-Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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