Document Detail

Effect of endurance exercise on respiratory muscle function in patients with cystic fibrosis.
MedLine Citation:
PMID:  22249283     Owner:  NLM     Status:  MEDLINE    
During exercise, patients with cystic fibrosis (CF) dynamically hyperinflate, which imposes both elastic and threshold loads on the inspiratory muscles and places them at a mechanical disadvantage due to muscle shortening. Conversely, dynamic hyperinflation imposes a progressively resistive load and lengthens the expiratory muscles potentially increasing their susceptibility to develop low frequency fatigue (LFF). The aim of the study was to determine whether high intensity endurance exercise leads to the development of LFF in either the diaphragm or expiratory abdominal wall muscles in patients with CF. Ten patients and ten healthy individuals were studied. Twitch transdiaphragmatic pressure (TwP(di)) and twitch abdominal pressure (TwT(10)) were measured before and after exhaustive endurance cycle exercise at 80% of their previously determined maximum work rate. There was no difference in TwP(di) or TwT(10) at 20, 40 or 60 min post exercise compared to pre-exercise resting values in any of the participants, indicating that overt LFF of the respiratory muscles did not develop.
Charles C Reilly; Katie Ward; Caroline J Jolley; Lucy A Frank; Caroline Elston; John Moxham; Gerrard F Rafferty
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-01-10
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  180     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-06     Completed Date:  2012-06-12     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  316-22     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
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MeSH Terms
Abdominal Muscles / physiology
Action Potentials / physiology
Anaerobic Threshold / physiology
Cystic Fibrosis / physiopathology*
Data Interpretation, Statistical
Diaphragm / physiology
Exercise / physiology*
Exercise Test
Forced Expiratory Volume / physiology
Muscle Fatigue / physiology
Muscle Strength / physiology
Physical Endurance / physiology*
Respiratory Mechanics / physiology
Respiratory Muscles / physiopathology*
Young Adult
Grant Support
G0500411//Medical Research Council; //Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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