| Effect of endurance exercise on myosin heavy chain gene regulation in human skeletal muscle. | |
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MedLine Citation:
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PMID: 9950919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to determine the effect of endurance-oriented exercise on myosin heavy chain (MHC) isoform regulation in human skeletal muscle. Exercise consisted of 1 h of cycle ergometer work per day at 75% maximal oxygen consumption for seven consecutive days. Muscle was obtained before the first bout of exercise, 3 h after the first bout of exercise, and before and 3 h after the final exercise bout on day 7 (n = 9 subjects). No changes in MHC mRNA (I, IIa, IIx) were evident after the first exercise period. There was, however, a significant (P < 0.05) decline (-30%) in MHC IIx mRNA 3 h after the final training bout. An interesting finding was that a higher pretraining level of MHC IIx mRNA was associated with a greater decline in the transcript before (r = 0.68, P < 0.05) and 3 h after (r = 0.82, P < 0.05) the final exercise bout. These findings suggest that MHC IIx mRNA is downregulated during the early phase of endurance-oriented exercise training in human skeletal muscle but only after repeated contractile activity. Pretraining MHC IIx mRNA content may influence the magnitude of this response. |
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Authors:
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D S O'Neill; D Zheng; W K Anderson; G L Dohm; J A Houmard |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 276 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1999 Feb |
Date Detail:
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Created Date: 1999-03-30 Completed Date: 1999-03-30 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R414-9 Citation Subset: IM; S |
Affiliation:
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Human Performance Laboratory, Department of Exercise and Sport Science, School of Medicine, East Carolina University, Greenville, North Carolina 27858, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Exercise / physiology* Gene Expression Regulation / physiology* Humans Isomerism Male Muscle, Skeletal / metabolism, physiology* Myosin Heavy Chains / genetics* Physical Endurance / physiology* RNA, Messenger / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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AG-10025/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Myosin Heavy Chains; 0/RNA, Messenger |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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