Document Detail

Effect of endurance exercise on myosin heavy chain gene regulation in human skeletal muscle.
MedLine Citation:
PMID:  9950919     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to determine the effect of endurance-oriented exercise on myosin heavy chain (MHC) isoform regulation in human skeletal muscle. Exercise consisted of 1 h of cycle ergometer work per day at 75% maximal oxygen consumption for seven consecutive days. Muscle was obtained before the first bout of exercise, 3 h after the first bout of exercise, and before and 3 h after the final exercise bout on day 7 (n = 9 subjects). No changes in MHC mRNA (I, IIa, IIx) were evident after the first exercise period. There was, however, a significant (P < 0.05) decline (-30%) in MHC IIx mRNA 3 h after the final training bout. An interesting finding was that a higher pretraining level of MHC IIx mRNA was associated with a greater decline in the transcript before (r = 0.68, P < 0.05) and 3 h after (r = 0.82, P < 0.05) the final exercise bout. These findings suggest that MHC IIx mRNA is downregulated during the early phase of endurance-oriented exercise training in human skeletal muscle but only after repeated contractile activity. Pretraining MHC IIx mRNA content may influence the magnitude of this response.
D S O'Neill; D Zheng; W K Anderson; G L Dohm; J A Houmard
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  276     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-03-30     Completed Date:  1999-03-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R414-9     Citation Subset:  IM; S    
Human Performance Laboratory, Department of Exercise and Sport Science, School of Medicine, East Carolina University, Greenville, North Carolina 27858, USA.
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MeSH Terms
Exercise / physiology*
Gene Expression Regulation / physiology*
Muscle, Skeletal / metabolism,  physiology*
Myosin Heavy Chains / genetics*
Physical Endurance / physiology*
RNA, Messenger / metabolism
Grant Support
Reg. No./Substance:
0/Myosin Heavy Chains; 0/RNA, Messenger

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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