Document Detail

Effect of endurance exercise on hepatic lipid content, enzymes, and adiposity in men and women.
MedLine Citation:
PMID:  18719669     Owner:  NLM     Status:  MEDLINE    
Obesity and physical inactivity are independent risk factors for the development of nonalcoholic fatty liver disease (NAFLD). We determined the effect of endurance exercise training on hepatic lipid content and hepatic enzyme concentration in men and women. Waist circumference (WC), percent body fat (BF), computed tomography (CT) scans for liver attenuation (inverse relationship with hepatic lipid), bilirubin, alanine aminotransferase (ALT), and gamma-glutamyltransferase (GGT) plasma concentrations were measured before and after 12 weeks of endurance training in 41 lean and obese men and women. Exercise training did not change liver attenuation, body weight, percent BF, bilirubin, or ALT concentration, but did lower WC (P < 0.0001), and decreased GGT in men only (P = 0.01). Obese subjects had a lower liver attenuation than lean subjects (P = 0.04). Obese women had lower ALT than obese men (P = 0.03). GGT was lower in women before and after training. WC was positively correlated with GGT (r = 0.32, P = 0.003) and ALT (r = 0.320, P = 0.004) and negatively correlated with liver attenuation (r = -0.340, P = 0.03). Percent BF was negatively correlated with bilirubin (r = -0.374, P = 0.005). Liver attenuation was negatively correlated with ALT (r = -0.405, P = 0.003). Short-term endurance training without weight loss does not alter hepatic lipid content. There was a strong relationship between GGT/ALT and body composition (percent BF) as well as between ALT and hepatic lipid content.
Michaela C Devries; Imtiaz A Samjoo; Mazen J Hamadeh; Mark A Tarnopolsky
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-31
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  16     ISSN:  1930-7381     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-15     Completed Date:  2008-10-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2281-8     Citation Subset:  IM    
Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.
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MeSH Terms
Alanine Transaminase / blood
Bilirubin / blood
Body Size
Body Weight
Energy Intake
Exercise Therapy*
Insulin Resistance
Lipid Metabolism*
Liver / enzymology*
Obesity / metabolism,  physiopathology,  therapy*
Sex Factors
Time Factors
Treatment Outcome
gamma-Glutamyltransferase / blood
Reg. No./Substance:
635-65-4/Bilirubin; EC; EC Transaminase

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