Document Detail


Effect of endotoxin on ventilation and breath variability: role of cyclooxygenase pathway.
MedLine Citation:
PMID:  11520726     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To evaluate the effects of endotoxemia on respiratory controller function, 12 subjects were randomized to receive endotoxin or saline; six also received ibuprofen, a cyclooxygenase inhibitor, and six received placebo. Administration of endotoxin produced fever, increased respiratory frequency, decreased inspiratory time, and widened alveolar-arterial oxygen tension gradient (all p < or = 0.001); these responses were blocked by ibuprofen. Independent of ibuprofen, endotoxin produced dyspnea, and it increased fractional inspiratory time, minute ventilation, and mean inspiratory flow (all p < or = 0.025). Endotoxin altered the autocorrelative behavior of respiratory frequency by increasing its autocorrelation coefficient at a lag of one breath, the number of breath lags with significant serial correlations, and its correlated fraction (all p < 0.05); these responses were blocked by ibuprofen. Changes in correlated behavior of respiratory frequency were related to changes in arterial carbon dioxide tension (r = 0.86; p < 0.03). Endotoxin decreased the oscillatory fraction of inspiratory time in both the placebo (p < 0.05) and ibuprofen groups (p = 0.06). In conclusion, endotoxin produced increases in respiratory motor output and dyspnea independent of fever and symptoms, and it curtailed the freedom to vary respiratory timing-a response that appears to be mediated by the cyclooxygenase pathway.
Authors:
H L Preas; A Jubran; R W Vandivier; D Reda; P J Godin; S M Banks; M J Tobin; A F Suffredini
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  164     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-24     Completed Date:  2001-10-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  620-6     Citation Subset:  AIM; IM    
Affiliation:
Critical Care Medicine Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Inflammatory Agents, Non-Steroidal / immunology,  pharmacology,  therapeutic use*
Blood Gas Analysis
Carbon Dioxide / blood
Dyspnea / drug therapy,  immunology*,  metabolism,  physiopathology*
Endotoxemia / drug therapy,  immunology*,  metabolism,  physiopathology*
Endotoxins / adverse effects*
Female
Fever / drug therapy,  immunology,  metabolism,  physiopathology
Humans
Ibuprofen / immunology,  pharmacology,  therapeutic use*
Inflammation
Male
Prostaglandin-Endoperoxide Synthases / drug effects*,  immunology*
Pulmonary Ventilation / drug effects*,  immunology*
Respiratory Muscles / drug effects,  immunology,  physiopathology
Sepsis / drug therapy,  immunology*,  metabolism,  physiopathology*
Single-Blind Method
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Endotoxins; 124-38-9/Carbon Dioxide; 15687-27-1/Ibuprofen; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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