Document Detail

Effect of endotoxin and allergens on neonatal lung function and infancy respiratory symptoms and eczema.
MedLine Citation:
PMID:  22435968     Owner:  NLM     Status:  Publisher    
To cite this article: Abbing-Karahagopian V, van der Gugten AC, van der Ent CK, Uiterwaal C, de Jongh M, Oldenwening M, Brunekreef B, Gehring U. Effect of endotoxin and allergens on neonatal lung function and infancy respiratory symptoms and eczema. Pediatric Allergy Immunology 2012: 00. ABSTRACT: Background:  Exposure to endotoxin and allergens in house dust has been found to be associated with childhood wheeze and asthma. Neonatal lung function is rarely examined in relation to this exposure. Objectives:  To assess the association between exposure to endotoxin, house dust mite and cat allergens and neonatal lung function, and respiratory symptoms and eczema in infancy. Methods:  In the Wheezing Illnesses Study Leidsche Rijn (WHISTLER) birth cohort study, levels of endotoxin, house dust mite allergens, and cat allergen have been measured in dust samples collected in the child's home. Lung function was measured before age 2 months, and respiratory symptoms and eczema were recorded in a daily diary during the first year of life. Associations of lung function (N = 302), respiratory symptoms (N = 361), and eczema (N = 342) with endotoxin and allergen levels have been studied by means of linear and logistic regression, respectively. Results:  Mattress dust endotoxin was associated with a significant increase in neonatal respiratory compliance [adjusted mean difference (95% confidence interval) 2.31 (0.33; 4.29) ml/kPa per interquartile range increase in exposure] and a non-significant decrease in neonatal airway resistance [0.32 (-0.77; 0.14) kPa/l/s]. There were no associations between allergen exposure and neonatal lung function and respiratory symptoms. Conclusions:  Environmental exposure to endotoxin may have an important role in the development of lung function.
Victoria Abbing-Karahagopian; Anne C van der Gugten; Cornelis K van der Ent; Cuno Uiterwaal; Madelon de Jongh; Marieke Oldenwening; Bert Brunekreef; Ulrike Gehring
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-22
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  -     ISSN:  1399-3038     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands Department of Pediatric Pulmonology, University Medical Center Utrecht, Utrecht, The Netherlands Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
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