Document Detail

Effect of endothelin blockade on pressure natriuresis in nitric oxide-deficient hypertensive rats.
MedLine Citation:
PMID:  10067799     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Chronic inhibition of nitric oxide synthesis has been shown to cause arterial hypertension and an important blunting of the pressure diuresis and natriuresis response. The mechanisms mediating these abnormalities are not completely established. We therefore studied the effects of endothelin on these alterations.
MATERIALS AND METHODS: Pressure diuretic and natriuretic relationships were evaluated in rats treated chronically (3 weeks) with the nitric oxide synthesis inhibitor N(omega)-nitro-L-arginine methyl ester (L-NAME; 40 mg/kg per day), alone or in combination with bosentan sodium salt (acute treatment: 10 mg/kg, intravenously; chronic treatment: 10 mg/kg per day).
RESULTS: Chronic treatment with L-NAME significantly elevated mean arterial pressure (143.7 +/- 2.8 mmHg versus 102.8 +/- 1.6 in controls), reduced the glomerular filtration rate and renal blood flow and shifted the pressure diuretic and natriuretic responses to the right. Treatment with bosentan, either acute or chronically, did not attenuate the arterial hypertension of the L-NAME-treated rats but normalized the glomerular filtration rate and renal blood flow. In spite of the normalization of renal hemodynamics, the pressure diuretic and natriuretic responses of the bosentan-treated groups were not normalized, although chronic bosentan significantly improved the pressure natriuretic response.
CONCLUSIONS: These results indicate that endothelin participates in the renal hemodynamic and excretory alterations that follow chronic inhibition of nitric oxide synthesis. However, the arterial hypertension is not mediated by endothelin activation.
L A Fortepiani; J J Janvier; M C Ortíz; N M Atucha; J García-Estañ
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  17     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-04-28     Completed Date:  1999-04-28     Revised Date:  2013-06-18    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  287-91     Citation Subset:  IM    
Departamento de Fisiología, Facultad de Medicina, Murcia, Spain.
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MeSH Terms
Antihypertensive Agents / pharmacology
Blood Flow Velocity / drug effects
Blood Pressure / drug effects
Diuresis / physiology
Endothelins / antagonists & inhibitors*,  metabolism
Enzyme Inhibitors / pharmacology
Glomerular Filtration Rate
Hypertension / metabolism*
Kidney / blood supply,  metabolism*
NG-Nitroarginine Methyl Ester / pharmacology
Natriuresis / physiology*
Nitric Oxide / antagonists & inhibitors*,  metabolism
Rats, Sprague-Dawley
Sulfonamides / pharmacology
Reg. No./Substance:
0/Antihypertensive Agents; 0/Endothelins; 0/Enzyme Inhibitors; 0/Sulfonamides; 10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; Q326023R30/bosentan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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