Document Detail

Effect of endothelin-3 on blood pressure in conscious spontaneously hypertensive [SHR] and DOCA-salt hypertensive rats.
MedLine Citation:
PMID:  8043901     Owner:  NLM     Status:  MEDLINE    
The aim of the study was to investigate blood pressure responses and changes in heart rate after bolus administration of endothelin-3 [ET-3] in conscious, freely moving SHR and WKY rats and DOCA-salt hypertensive and normotensive Wistar rats. The effect of ET-3 on blood pressure and heart rats was investigated for four doses equal to 250 ng, 500 ng, 1000 ng and 2000 ng of ET-3. Our study shows that in experimental models of hypertension changes in blood pressure were predominantly characterized by the pronounced hypotensive phase with no significant raises in blood pressure. In normotensive animals cardiovascular responses to ET-3 were biphasic, with initial depressor phase followed by long-lasting, significant pressor effect.
A Januszewicz; S Loń; M Lapiński; A Styś
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  45     ISSN:  0867-5910     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-08-26     Completed Date:  1994-08-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  105-19     Citation Subset:  IM    
Department of Hypertension and Angiology, Warsaw Academy of Medicine, Poland.
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MeSH Terms
Blood Pressure / drug effects*
Body Weight / drug effects
Endothelins / pharmacology*
Heart Rate / drug effects
Hypertension / chemically induced,  physiopathology*
Rats, Inbred SHR
Rats, Inbred WKY
Rats, Wistar
Reg. No./Substance:
0/Endothelins; 64-85-7/Desoxycorticosterone

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