Document Detail

Effect of endothelin-1 on exercise-induced vasodilation in normal subjects and in patients with heart failure.
MedLine Citation:
PMID:  9468084     Owner:  NLM     Status:  MEDLINE    
Forearm blood flow (ml/min/100 ml) was determined with strain-gauge venous occlusion plethysmography at rest and in response to handgrip exercise in 7 patients with congestive heart failure and in 9 normal subjects before and after regional administration of endothelin-1 in the brachial artery. Administration of endothelin-1 significantly decreased forearm blood flow at rest and during exercise in normal subjects but did not change it at rest or during exercise in patients with congestive heart failure.
H Krum; S D Katz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  81     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-02-26     Completed Date:  1998-02-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  355-8     Citation Subset:  AIM; IM    
Columbia Presbyterian Medical Center, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.
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MeSH Terms
Brachial Artery / physiology*
Endothelin-1 / physiology*
Exercise / physiology*
Exercise Test
Forearm / blood supply
Hand Strength
Heart Failure / physiopathology*
Middle Aged
Muscle, Smooth, Vascular / physiology*
Regional Blood Flow / physiology
Vasodilation / physiology*
Grant Support
1 R29 HL51433-01A1/HL/NHLBI NIH HHS; 5M01RR00645/RR/NCRR NIH HHS
Reg. No./Substance:

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