Document Detail

Effect of endometriosis on in vitro fertilization.
MedLine Citation:
PMID:  12057720     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the IVF outcome for patients with endometriosis. DESIGN: Meta-analysis. SETTING: Academic research center. PATIENT(S): A MEDLINE search and review of the literature were performed. Patients were classified by level of endometriosis, and controls were classified according to the indication for IVF. INTERVENTION(S): Bivariate analysis and multivariate logistic regression was used to estimate overall effect and control for confounding. MAIN OUTCOME MEASURE(S): Pregnancy rates, fertilization rate, implantation rates, and numbers of oocytes retrieved. RESULT(S): Twenty-two published studies were included in the overall analysis. The chance of achieving pregnancy was significantly lower for endometriosis patients (odds ratio, 0.56; 95% confidence interval, 0.44-0.70) when compared with tubal factor controls. Multivariate analysis also demonstrated a decrease in fertilization and implantation rates, and a significant decrease in the number of oocytes retrieved for endometriosis patients. Pregnancy rates for women with severe endometriosis were significantly lower than for women with mild disease (odds ratio, 0.60; 95% confidence interval, 0.42-0.87). CONCLUSION(S): Patients with endometriosis-associated infertility undergoing IVF respond with significantly decreased levels of all markers of reproductive process, resulting in a pregnancy rate that is almost one half that of women with other indications for IVF. These data suggest that the effect of endometriosis is not exclusively on the receptivity of the endometrium but also on the development of the oocyte and embryo.
Kurt Barnhart; Rebecca Dunsmoor-Su; Christos Coutifaris
Publication Detail:
Type:  Journal Article; Meta-Analysis    
Journal Detail:
Title:  Fertility and sterility     Volume:  77     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-11     Completed Date:  2002-07-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1148-55     Citation Subset:  IM    
Center for Reproductive Medicine and Surgery, University of Pennsylvania Medical Center and Health System, Philadelphia, Pennsylvania, USA.
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MeSH Terms
Cell Count
Embryo Implantation
Endometriosis / physiopathology*
Fertilization in Vitro*
Oocytes / cytology
Pregnancy Rate
Severity of Illness Index
Tissue and Organ Harvesting
Comment In:
Fertil Steril. 2002 Dec;78(6):1350-1; author reply 1351   [PMID:  12477548 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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