| Effect of endogenous progesterone and oestradiol-17beta on the incidence of gastro-oesophageal reflux and on the barrier pressure during general anaesthesia in the female dog. | |
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MedLine Citation:
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PMID: 19470143 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the potential effect of increased blood progesterone (P(4)) and oestradiol-17beta (E(2)) concentrations on the barrier pressure (BrP) and the incidence of gastro-oesophageal reflux (GOR) in female dogs under general anaesthesia. STUDY DESIGN: Prospective, blinded experimental trial. ANIMALS: Seven female, adult, healthy dogs weighing 14-21 kg and aged 1-7 years. METHODS: Each of the animals was studied under the influence of high blood E(2) and basal P(4) (study O), basal E(2) and high P(4) (study P) and basal E(2) and P(4) (study C) concentrations. Animals were premedicated with acepromazine and anaesthesia was induced with thiopental and maintained with halothane. Lower oesophageal pH was monitored continuously for 1 hour after induction. GOR was defined as oesophageal pH >7.5 or <4. Manometry of the posterior oesophageal sphincter (POS) was then performed using the slow pull-through technique. RESULTS: Acid GOR was detected in only one animal of study O. The three studies did not differ significantly in GOR. Mean BrP was 11.2 (study O), 9.1 (study P) and 11.6 mmHg (study C). No significant differences were detected with respect to mean BrP, intra-gastric pressure and POS pressure. CONCLUSIONS: It is unlikely that the increased concentrations of E(2) or P(4) during the normal ovarian cycle influence the functional efficiency of the POS as a major barrier to GOR in healthy, female dogs under general anaesthesia. CLINICAL RELEVANCE: The fact that female dogs undergoing obstetrical surgery represented a substantial sub-group of the animals which developed postoperative benign oesophageal stricture, should probably not be attributed to the effects of increased concentrations of female sex steroid hormones. |
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Authors:
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Tilemahos L Anagnostou; Ioannis Savvas; George M Kazakos; Haralabos N Ververidis; Maria-Rea Haritopoulou; Timoleon S Rallis; Dimitris Raptopoulos |
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Publication Detail:
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Type: Journal Article Date: 2009-05-12 |
Journal Detail:
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Title: Veterinary anaesthesia and analgesia Volume: 36 ISSN: 1467-2995 ISO Abbreviation: Vet Anaesth Analg Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-22 Completed Date: 2009-10-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100956422 Medline TA: Vet Anaesth Analg Country: England |
Other Details:
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Languages: eng Pagination: 308-18 Citation Subset: IM |
Affiliation:
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Anaesthesia and Intensive Care Unit, Department of Clinical Sciences, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece. tanagnos@vet.auth.gr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia, General
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adverse effects,
veterinary* Animals Dog Diseases / chemically induced* Dogs Dose-Response Relationship, Drug Esophagogastric Junction / drug effects* Estradiol / blood* Estrous Cycle / blood, physiology Female Gastroesophageal Reflux / chemically induced* Pressure Progesterone / blood* Thiopental / administration & dosage, pharmacology |
| Chemical | |
Reg. No./Substance:
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50-28-2/Estradiol; 57-83-0/Progesterone; 76-75-5/Thiopental |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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