Document Detail

Effect of end groups of poly(n-butyl methacrylate) on its biocompatibility.
MedLine Citation:
PMID:  19608387     Owner:  NLM     Status:  MEDLINE    
Telechelic poly(n-butyl methacrylate)s (PBMAs) with various end groups were prepared using nonionic, anionic, cationic or zwitterionic azo-type radical initiators and cell adhesion onto the surfaces of the polymers was investigated. The tendency for cell adhesion to the polymers differed with and without pretreatment with phosphate-buffered saline (PBS, pH 7.4). The cell adhesion to polymer surfaces without pretreatment was lower than that with pretreatment. The effect of pretreatment with PBS was significant for PBMA with ionic end groups. Furthermore, cell adhesion to the surface of PBMA with zwitterionic end groups was suppressed compared with that to the surfaces of other polymers. It was presumed that positive and negative charges of zwitterionic groups in the same molecule negated each other at pH 7.4 and that the polymers with zwitterionic end groups had no effective charges. The results clearly indicated that biocompatibility of polymers can be changed by the introduction of functional groups at the ends of the polymer chains. Fabrication of functional material surfaces will be anticipated by the similar method in the future.
Shigeto Fujishita; Chika Inaba; Takuya Ishisaka; Makoto Gemmei-Ide; Hiromi Kitano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-23
Journal Detail:
Title:  Colloids and surfaces. B, Biointerfaces     Volume:  74     ISSN:  1873-4367     ISO Abbreviation:  Colloids Surf B Biointerfaces     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-09-28     Completed Date:  2009-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9315133     Medline TA:  Colloids Surf B Biointerfaces     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  45-50     Citation Subset:  IM    
Department of Applied Chemistry, Graduate School of Science and Engineering, University of Toyama, Gofuku 3190, Toyama 930-8555, Japan.
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MeSH Terms
Biocompatible Materials / chemistry,  pharmacology*
Cell Adhesion / drug effects
Fibroblasts / cytology,  drug effects
Materials Testing*
Polymers / chemistry
Polymethacrylic Acids / chemistry*
Surface Properties / drug effects
Reg. No./Substance:
0/Biocompatible Materials; 0/Polymers; 0/Polymethacrylic Acids; 9003-63-8/polybutyl methacrylate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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