| Effect of enalapril treatment on the pressure-natriuresis curve in spontaneously hypertensive rats. | |
| | |
MedLine Citation:
|
PMID: 1986983 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effect of chronic angiotensin I converting enzyme inhibition on the pressure-natriuresis relation was studied in Wistar-Kyoto and spontaneously hypertensive rats. Enalapril maleate (25 mg.kg-1.day-1 in drinking water) was started at 4-5 weeks of age. At 7-9 weeks of age, the pressure-natriuresis relation was studied while the rats were under Inactin anesthesia 1 week after the right kidney and adrenal gland were removed. Neural and hormonal influences on the remaining kidney were fixed by surgical renal denervation, adrenalectomy, and infusion of a hormone cocktail (330 microliters.kg-1.min-1) containing high levels of aldosterone, arginine vasopressin, hydrocortisone, and norepinephrine dissolved in 0.9% NaCl containing 1% albumin. Changes in renal function resulting from alterations in renal artery pressure were compared between enalapril-treated and control rats. Mean arterial pressure (+/- SEM) under anesthesia was 118 +/- 5, 94 +/- 4, 175 +/- 3, and 124 +/- 2 mm Hg for control Wistar-Kyoto (n = 10), enalapril-treated Wistar-Kyoto (n = 10), control spontaneously hypertensive (n = 9), and enalapril-treated spontaneously hypertensive (n = 9) rats, respectively. When renal artery pressure was set at values above approximately 125 mm Hg, control spontaneously hypertensive rats excreted less sodium and water than control Wistar-Kyoto rats. Enalapril treatment resulted in a significant and similar shift to the left of the pressure-natriuresis relation in both strains of rats so that a lower renal artery pressure was required to excrete a similar amount of sodium when compared with their respective untreated controls.(ABSTRACT TRUNCATED AT 250 WORDS) |
| | |
Authors:
|
G P McLennan; R L Kline; P F Mercer |
Related Documents
:
|
21401393 - Second prize: in-vivo physiological impact of alpha blockade on the porcine ureter with... 18935913 - Variations in blood pressure and heart rate in conscious rats with cervical lymphatic b... 7806763 - Effects of centrally administered endothelin-3 on renal sympathetic nerve activity and ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Hypertension Volume: 17 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1991 Jan |
Date Detail:
|
Created Date: 1991-02-19 Completed Date: 1991-02-19 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 54-62 Citation Subset: IM |
Affiliation:
|
Department of Physiology, University of Western Ontario, London, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure / drug effects* Drinking / drug effects Enalapril / pharmacology* Male Natriuresis / drug effects* Rats Rats, Inbred SHR / physiology* Rats, Inbred WKY Renal Artery Renal Circulation / drug effects |
| Chemical | |
Reg. No./Substance:
|
75847-73-3/Enalapril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Renal manifestations of NaCl sensitivity in borderline hypertensive rats.
Next Document: Rapid baroreceptor resetting in chronic hypertension. Implications for normalization of arterial pre...