Document Detail

Effect of enalapril at rest, during tilt, static and dynamic exercise in systemic hypertension.
MedLine Citation:
PMID:  2988326     Owner:  NLM     Status:  MEDLINE    
Using the "Oxford system" for ambulatory monitoring of direct arterial blood pressure (BP), the hypotensive effect of enalapril (20 to 40 mg/day), was assessed in 15 patients with essential hypertension. BP was reduced by enalapril throughout the 24 hours of study. A within-patient comparison of corresponding mean hourly systolic and diastolic BP values showed a reduction from (p less than 0.05 to p less than 0.001) for 18 of the 24 hours. Four patients had an increase in BP during treatment with enalapril. There was a significant decrease in systolic BP in response to 60 degrees head-up tilt. During isometric and dynamic exercise there was a smaller increase in systolic BP but a less marked effect on diastolic BP. Heart rate was unaffected either during free ambulation or during physiologic testing. The incidence of side effects was low. These results indicate that enalapril administered once daily may be an effective form of antihypertensive therapy. However, there is a group of patients who are unresponsive to treatment with converting enzyme inhibitors.
R I Jones; R S Hornung; P M Cashman; E B Raftery
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  55     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-07-25     Completed Date:  1985-07-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1534-8     Citation Subset:  AIM; IM; S    
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MeSH Terms
Blood Pressure / drug effects
Dipeptides / administration & dosage,  therapeutic use*
Heart Rate / drug effects
Hypertension / drug therapy*,  physiopathology
Middle Aged
Physical Exertion
Reg. No./Substance:
0/Dipeptides; 75847-73-3/Enalapril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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