Document Detail

Effect of embryo transfer number on singleton and twin implantation pregnancy outcomes after assisted reproductive technology.
MedLine Citation:
PMID:  21043364     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the effect of embryo transfer number on singleton and twin pregnancy outcomes with one and two fetal heartbeats on early ultrasound, respectively.
STUDY DESIGN: The study included 23,645 singleton and 14,083 twin live births from the SART-CORS Online database of assisted reproductive technology cycles for 2004-2006. The data were limited to fresh embryo transfers among women who had additional embryos cryopreserved during the same cycle, resulting either in one fetal heartbeat on early ultrasound and a singleton live birth, or two fetal heartbeats and a twin live birth. Data were categorized by number of embryos transferred; the reference group was one for singletons and two for twins. The primary outcome measure was moderate growth restriction (birthweight for gestation z-score < -1), adjusted for potential confounders.
RESULTS: Risk for moderate growth restriction among singletons was increased by 15%, 23%, and 37%, respectively, with 2, 3, and > or = 4 embryos transferred, and among twins, by 50% and 105%, respectively, with 3 and > or = 4 embryos transferred.
CONCLUSION: The data demonstrate a significant residual adverse effect on intrauterine growth from transfer of multiple embryos. Whether this effect is due to compromised embryo quality, degenerating implantation sites, or other etiology is unclear.
Barbara Luke; Morton B Brown; Judy E Stern; David A Grainger; Nancy Klein; Marcelle Cedars
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  55     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-11-03     Completed Date:  2010-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  387-94     Citation Subset:  IM    
Department of Obstetrics and Gynecology and Reproductive Biology, Michigan State Univesity, East Lansing, Michigan 48824, USA.
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MeSH Terms
Embryo Implantation
Embryo Transfer / adverse effects*,  methods
Fetal Growth Retardation / etiology*
Infant, Low Birth Weight
Infant, Newborn
Live Birth*
Middle Aged
Odds Ratio
Pregnancy Outcome
Retrospective Studies
Risk Assessment
Ultrasonography, Prenatal*
Young Adult

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