| Effect of embryo transfer number on singleton and twin implantation pregnancy outcomes after assisted reproductive technology. | |
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MedLine Citation:
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PMID: 21043364 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the effect of embryo transfer number on singleton and twin pregnancy outcomes with one and two fetal heartbeats on early ultrasound, respectively. STUDY DESIGN: The study included 23,645 singleton and 14,083 twin live births from the SART-CORS Online database of assisted reproductive technology cycles for 2004-2006. The data were limited to fresh embryo transfers among women who had additional embryos cryopreserved during the same cycle, resulting either in one fetal heartbeat on early ultrasound and a singleton live birth, or two fetal heartbeats and a twin live birth. Data were categorized by number of embryos transferred; the reference group was one for singletons and two for twins. The primary outcome measure was moderate growth restriction (birthweight for gestation z-score < -1), adjusted for potential confounders. RESULTS: Risk for moderate growth restriction among singletons was increased by 15%, 23%, and 37%, respectively, with 2, 3, and > or = 4 embryos transferred, and among twins, by 50% and 105%, respectively, with 3 and > or = 4 embryos transferred. CONCLUSION: The data demonstrate a significant residual adverse effect on intrauterine growth from transfer of multiple embryos. Whether this effect is due to compromised embryo quality, degenerating implantation sites, or other etiology is unclear. |
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Authors:
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Barbara Luke; Morton B Brown; Judy E Stern; David A Grainger; Nancy Klein; Marcelle Cedars |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of reproductive medicine Volume: 55 ISSN: 0024-7758 ISO Abbreviation: J Reprod Med Publication Date: 2010 Sep-Oct |
Date Detail:
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Created Date: 2010-11-03 Completed Date: 2010-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0173343 Medline TA: J Reprod Med Country: United States |
Other Details:
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Languages: eng Pagination: 387-94 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology and Reproductive Biology, Michigan State Univesity, East Lansing, Michigan 48824, USA. lukeb@msu.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Embryo Implantation Embryo Transfer / adverse effects*, methods Female Fetal Growth Retardation / etiology* Humans Infant, Low Birth Weight Infant, Newborn Live Birth* Middle Aged Odds Ratio Pregnancy Pregnancy Outcome Retrospective Studies Risk Assessment Twins* Ultrasonography, Prenatal* Young Adult |
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