Document Detail


Effect of embryo transfer number on singleton and twin implantation pregnancy outcomes after assisted reproductive technology.
MedLine Citation:
PMID:  21043364     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the effect of embryo transfer number on singleton and twin pregnancy outcomes with one and two fetal heartbeats on early ultrasound, respectively.
STUDY DESIGN: The study included 23,645 singleton and 14,083 twin live births from the SART-CORS Online database of assisted reproductive technology cycles for 2004-2006. The data were limited to fresh embryo transfers among women who had additional embryos cryopreserved during the same cycle, resulting either in one fetal heartbeat on early ultrasound and a singleton live birth, or two fetal heartbeats and a twin live birth. Data were categorized by number of embryos transferred; the reference group was one for singletons and two for twins. The primary outcome measure was moderate growth restriction (birthweight for gestation z-score < -1), adjusted for potential confounders.
RESULTS: Risk for moderate growth restriction among singletons was increased by 15%, 23%, and 37%, respectively, with 2, 3, and > or = 4 embryos transferred, and among twins, by 50% and 105%, respectively, with 3 and > or = 4 embryos transferred.
CONCLUSION: The data demonstrate a significant residual adverse effect on intrauterine growth from transfer of multiple embryos. Whether this effect is due to compromised embryo quality, degenerating implantation sites, or other etiology is unclear.
Authors:
Barbara Luke; Morton B Brown; Judy E Stern; David A Grainger; Nancy Klein; Marcelle Cedars
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  55     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-11-03     Completed Date:  2010-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  387-94     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology and Reproductive Biology, Michigan State Univesity, East Lansing, Michigan 48824, USA. lukeb@msu.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Embryo Implantation
Embryo Transfer / adverse effects*,  methods
Female
Fetal Growth Retardation / etiology*
Humans
Infant, Low Birth Weight
Infant, Newborn
Live Birth*
Middle Aged
Odds Ratio
Pregnancy
Pregnancy Outcome
Retrospective Studies
Risk Assessment
Twins*
Ultrasonography, Prenatal*
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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