Document Detail

Effect of elevated dissolved carbon dioxide concentrations on growth of Corynebacterium glutamicum on D-glucose and L-lactate.
MedLine Citation:
PMID:  17275119     Owner:  NLM     Status:  MEDLINE    
The effect of increased dissolved carbon dioxide concentrations on growth of Corynebacterium glutamicum was studied with continuous turbidostatic cultures. The carbon sources were either l-lactate or d-glucose. To increase the dissolved carbon dioxide concentration the carbon dioxide partial pressure of the inlet gas stream pCO2,IN was increased stepwise from 0.0003 bar (air) up to 0.79 bar, while the oxygen partial pressure of the inlet gas stream was kept constant at 0.21 bar. For each resulting carbon dioxide partial pressure pCO2 the maximum specific growth rate mu(max) was determined from the feed rate resulting from the turbidostatic control. On d-glucose and pCO2 up to 0.26 bar, mu(max) was mostly constant around 0.58 h(-1). Higher pCO2 led to a slight decrease of mu(max). On l-lactate mu(max) increased gradually with increasing carbon dioxide partial pressures from 0.37 h(-1) under aeration with air to a maximum value of 0.47 h(-1) at a pCO2 of 0.26 bar. At very high pCO2 (0.81 bar) mu(max) decreased down to 0.35 h(-1) independent of the carbon source.
Carsten Bäumchen; Arnd Knoll; Bernward Husemann; Juri Seletzky; Bernd Maier; Carsten Dietrich; Ghassem Amoabediny; Jochen Büchs
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Publication Detail:
Type:  Journal Article     Date:  2007-01-10
Journal Detail:
Title:  Journal of biotechnology     Volume:  128     ISSN:  0168-1656     ISO Abbreviation:  J. Biotechnol.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-09     Completed Date:  2007-05-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8411927     Medline TA:  J Biotechnol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  868-74     Citation Subset:  IM    
Biochemical Engineering, RWTH Aachen University, D-52074 Aachen, Germany.
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MeSH Terms
Carbon Dioxide / pharmacology*
Corynebacterium glutamicum / drug effects*,  growth & development,  metabolism
Glucose / metabolism
Lactic Acid / metabolism
Partial Pressure
Reg. No./Substance:
124-38-9/Carbon Dioxide; 50-21-5/Lactic Acid; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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