Document Detail

Effect of elevated atrial pressure on plasma renin activity in hypotensive fetal lambs.
MedLine Citation:
PMID:  8342701     Owner:  NLM     Status:  MEDLINE    
In adults, renin secretion is stimulated by reductions in arterial pressure and inhibited by increases in atrial pressure. In the late gestation fetus, a fall in arterial pressure stimulates renin secretion, but it is unknown whether elevation of atrial pressure will alter such an increase. Therefore we studied the effect of elevated atrial pressure on renin secretion in the presence of nitroprusside-induced arterial hypotension. Thirteen fetal lambs at 127.9 +/- 0.9 days of gestation were prepared 5 days before study with inflatable pulmonary artery occluders and right atrial, vascular, and amniotic catheters. Each fetus underwent two protocols (hypotension and hypotension with occlusion) using a randomized block design. Nitroprusside reduced arterial pressure by 34% in both groups. Right atrial pressure during the course of hypotension was significantly higher in the occlusion group (F = 14.2, P = 0.001). Plasma renin activity increased similarly in both groups during hypotension (F = 6.0, P = 0.003). Elevated right atrial pressure did not alter hypotension-induced renin secretion in the fetus.
A U Sheikh; L K Washburn; R K Jaekle; J C Rose
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  265     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-08-27     Completed Date:  1993-08-27     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R76-81     Citation Subset:  IM    
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MeSH Terms
Blood Pressure*
Cardiovascular System / embryology
Fetal Blood* / metabolism
Fetus / physiology*
Heart Atria
Hypotension / blood*,  physiopathology*
Renin / blood*
Grant Support
Reg. No./Substance:

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