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Effect of electro-acupuncture on tumor necrosis factor-α and vascular endothelial growth factor in peripheral blood and joint synovia of patients with rheumatoid arthritis.
MedLine Citation:
PMID:  21725875     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: To observe the effect of electro-acupuncture (EA) on tumor necrosis factor-α (TNF-α) and vascular endothelial growth factor (VEGF) in peripheral blood and joint synovia in patients with rheumatoid arthritis (RA) to verify the clinical efficacy of EA.
METHODS: Adopting randomized controlled principle, the 63 RA patients enrolled were assigned to two groups, the 32 patients in the EA group were treated with EA, and the 31 patients in the simple needling (SN) group treated with simple needling. According to the integral-local combining method, the acupoints were selected mainly from yang-meridian and local Ashi points (pain-point). EA or SN was applied every other day, 10 times as a course, and each patient received a total of 3 courses of treatment.
RESULTS: Blood and synovial levels of TNF-α and VEGF were reduced significantly after treatment in both groups. The lowering (absolute value and difference value) of TNF-α as well as the absolute value of VEGF, either in blood or in synovia, were similar in the two groups (P>0.05); but the lowering of VEGF after treatment was more significant in the EA group than that in the SN group (P<0.05).
CONCLUSION: EA could effectively lower the contents of TNF-α and VEGF in peripheral blood and joint synovia to improve the internal environment for genesis and development of RA, so as to enhance the clinical therapeutic effectiveness.
Ba-Si Ouyang; Jie Gao; Jian-Li Che; Yin Zhang; Jun Li; Hai-Zhou Yang; Tian-Yan Hu; Man Yang; Yuan-Jian Wu; Ling-Ling Ji
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Publication Detail:
Type:  Journal Article     Date:  2011-07-03
Journal Detail:
Title:  Chinese journal of integrative medicine     Volume:  17     ISSN:  1672-0415     ISO Abbreviation:  Chin J Integr Med     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101181180     Medline TA:  Chin J Integr Med     Country:  China    
Other Details:
Languages:  eng     Pagination:  505-9     Citation Subset:  IM    
Suzhou Hospital of Traditional Chinese Medicine, Suzhou, Jiangsu Province, 215003, China,
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