| Effect of electrical tooth stimulation on blood flow, interstitial fluid pressure and substance P and CGRP-immunoreactive nerve fibers in the low compliant cat dental pulp. | |
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MedLine Citation:
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PMID: 7521929 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of vasodilation on simultaneously measured interstitial fluid pressure (IFP, micropuncture) and blood flow (laser-Doppler) in the low compliant pulpal connective tissue was investigated in 10 cats. Vasodilation was induced by electrical stimulation of the tooth after pretreatment with the sympathetic blocker guanethidine. Visualization of the sensory neuropeptides calcitonin gene-related peptide (CGRP) and substance P (SP) was performed using immunocytochemistry. The study was designed to answer the following questions. (1) Does vasodilation promptly increase IFP in low compliant tissues? (2) Does an increase in IFP counteract the blood flow increase? (3) Does repeated electrical stimulation cause reduced staining of CGRP- and SP-immunoreactive nerve fibers in the dental pulp? Electrical stimulation resulted consistently in a nearly synchronous increase in both blood flow and IFP. IFP was nearly doubled, from 6.3 +/- 0.18 mm Hg in control to 11.7 +/- 0.44 mm Hg, whereas blood flow increased by 28%. However, despite continued vasodilation the IFP fell to control level, or even lower, within 1-5 min. The results indicate that the increased IFP will promote fluid absorption into the blood, counteracting a further IFP increase in low compliant tissues during vasodilation. Accordingly, transmural pressure is only transitorily reduced and compression of vessels does not take place. There was considerably less CGRP- and SP-immunoreactive fibers in the stimulated teeth than in the contralateral controls, suggesting that the vasodilation was caused by liberation of these sensory neuropeptides. |
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Authors:
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K J Heyeraas; S Kim; W H Raab; M R Byers; M Liu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Microvascular research Volume: 47 ISSN: 0026-2862 ISO Abbreviation: Microvasc. Res. Publication Date: 1994 May |
Date Detail:
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Created Date: 1994-10-11 Completed Date: 1994-10-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0165035 Medline TA: Microvasc Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 329-43 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of Bergen, Norway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity Blood Pressure / physiology Calcitonin Gene-Related Peptide / metabolism Cats Dental Pulp / blood supply*, innervation, physiology Electric Stimulation Extracellular Space / physiology Female Immunohistochemistry Male Nerve Fibers / metabolism Pressure Substance P / metabolism Vasodilation / physiology |
| Grant Support | |
ID/Acronym/Agency:
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DEO5159/DE/NIDCR NIH HHS; DEO5605/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
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33507-63-0/Substance P; 83652-28-2/Calcitonin Gene-Related Peptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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