Document Detail

Effect of elastase on primary graft patency after femoralpopliteal arterial bypass for arteriosclerosis obliterans: a randomized, controlled study.
MedLine Citation:
PMID:  9189814     Owner:  NLM     Status:  MEDLINE    
METHODS: Studies were carried out on 104 limbs with femoralpopliteal bypasses for arteriosclerosis obliterans (ASO). They were randomized to a group receiving elastase (10800 EL. U. P.O. per day) with an antiplatelet drug (Elastase group, 58 patients) or a group receiving only the antiplatelet drug (Control group, 46 patients). The follow-up period ranged from 24 to 36 months after operation at 22 institutions across Japan. RESULTS: The cumulative graft patency rate was higher in the Elastase group than the Control group, but the difference lacked statistical significance. When autogenous saphenous veins were used, the cumulative graft patency rate was significantly higher in the Elastase group than the Control group. CONCLUSIONS: The present study suggests that elastase is effective in maintaining graft patency in femoralpopliteal arterial bypass when an autogenous saphenous vein is used as a graft.
K Fujioka; K Esato; N Zempo
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International surgery     Volume:  82     ISSN:  0020-8868     ISO Abbreviation:  Int Surg     Publication Date:    1997 Jan-Mar
Date Detail:
Created Date:  1997-07-17     Completed Date:  1997-07-17     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0043524     Medline TA:  Int Surg     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  94-7     Citation Subset:  IM    
First Department of Surgery, Yamaguchi University School of Medicine, Japan.
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MeSH Terms
Arteriosclerosis Obliterans / physiopathology,  surgery*
Blood Vessel Prosthesis
Drug Therapy, Combination
Femoral Artery / surgery*
Middle Aged
Pancreatic Elastase / therapeutic use*
Platelet Aggregation Inhibitors / therapeutic use*
Popliteal Artery / surgery*
Saphenous Vein / transplantation
Transplantation, Autologous
Vascular Patency / drug effects*
Vascular Surgical Procedures / methods
Reg. No./Substance:
0/Platelet Aggregation Inhibitors; EC Elastase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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