Document Detail


Effect of eczema on the association between season of birth and food allergy in Japanese children.
MedLine Citation:
PMID:  22978473     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Food allergy (FA) in childhood has been shown to be more prevalent in those born in autumn and winter. The mechanisms of this "season of birth" effect remain unclear, although shortage of vitamin D during infancy has been considered one possible mechanism. The purpose of this study was to investigate the effect of eczema on the "season of birth effect" on FA in infancy. METHODS: A questionnaire survey dealing with the prevalence of allergic diseases was administered to the parents of 14,669 Japanese schoolchildren, aged 7 to 15 years, in Kyoto City, Japan. Logistic regression models were constructed to compare the prevalence of FA in infancy according to season of birth. RESULTS: Those born in autumn and winter showed a significantly higher prevalence of FA in infancy compared to those born in spring and summer in a multivariate model (4.8% vs. 3.6%, p=0.001). However, the difference was no longer significant when eczema before 6 months was included as either an additional or only confounding factor. The difference among those with and without eczema before 6 months was further analyzed, and it was found that, in both groups, there was no difference between those born in spring and summer and those born in autumn and winter. CONCLUSIONS: The "season of birth effect" on FA in infancy was significantly affected by the existence of eczema before 6 months in Japanese children. Eczema before 6 months may be the factor directly related to the "season of birth effect" on FA in infancy.
Authors:
Takashi Kusunoki; Takeshi Morimoto; Mio Sakuma; Kumiko Mukaida; Takahiro Yasumi; Ryuta Nishikomori; Toshio Heike
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-17
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  -     ISSN:  1442-200X     ISO Abbreviation:  Pediatr Int     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Author. Pediatrics International © 2012 Japan Pediatric Society.
Affiliation:
Department of Pediatrics, Shiga Medical Center for Children, Shiga, Japan; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
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