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Effect of early physical activity on long-term outcome after venous thrombosis.
MedLine Citation:
PMID:  19898077     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
OBJECTIVE: To determine if the level of self-reported physical activity 1 month after deep vein thrombosis (DVT) is associated with the risk of post-thrombotic syndrome (PTS) in the first 2 years post-DVT. DESIGN: Prospective cohort study. SETTING: Multicenter study (8 hospitals). PARTICIPANTS: Patients presenting with objectively diagnosed acute DVT to 8 hospitals in Quebec and Ontario, Canada. ASSESSMENT OF RISK FACTORS: We used validated questionnaires to measure physical activity (Godin questionnaire) and venous disease severity [generic physical quality of life (SF-36 PCS scale) or VEINES-QOL]. We adjusted for potential confounding effects of age, sex, and body mass index. We used multiple imputation to account for missing data. MAIN OUTCOME MEASURES: Post-thrombotic syndrome (validated Villalta scale). RESULTS: For the 387 patients enrolled, univariate analysis suggested no association between 1-month activity and risk of PTS. After adjusting for missing data and potential confounders, there was no evidence of a trend toward increasing risk of PTS with increasing physical activity [1.65 (95% confidence interval, 0.87-3.14) for mild-moderate activity and 1.35 (95% confidence interval, 0.69-2.67) for high activity]. The results were similar when PTS was dichotomized as none/mild versus moderate/severe. Finally, patients with PTS had lower levels of activity at 2 years post-DVT. CONCLUSIONS: The level of self-reported exercise in the first month post-DVT is not associated with an increased risk of PTS in the first 2 years after DVT. Post-thrombotic syndrome is associated with decreased levels of physical activity 2 years after DVT.
Authors:
Ian Shrier; Susan R Kahn; Russell J Steele
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine     Volume:  19     ISSN:  1536-3724     ISO Abbreviation:  Clin J Sport Med     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9103300     Medline TA:  Clin J Sport Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  487-93     Citation Subset:  IM    
Affiliation:
Centre for Clinical Epidemiology and Community Studies, Lady Davis Institute for Medical Research, SMBD-Jewish General Hospital, Montreal, Quebec, Canada. ian.shrier@mcgill.ca
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