| Effect of early oral fluoroquinolones in hemorrhagic colitis due to Escherichia coli O157:H7. | |
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MedLine Citation:
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PMID: 10221035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During the Sakai outbreak of Escherichia coli O157:H7 infection, which was linked to contaminated cafeteria school lunches, there were several treatment modalities with regard to antimicrobial drugs. Patient outcomes among three hospitals with different modalities were compared retrospectively. Hemolytic uremic syndrome did not develop in any of the 15 patients treated with oral fluoroquinolone therapy; however, HUS did develop in three of 15 patients treated with intravenous (i.v.) fosfomycin and in two of 12 patients treated with i.v. cefotaxime and oral fosfomycin. The results indicate that oral fluoroquinolone therapy administered within 3 days of illness is effective in preventing the development of HUS; however, prospective randomized double-blind studies on early antimicrobial therapy of O157 hemorrhagic colitis are necessary. Several antibiotics, including fluoroquinolones, were reported to induce the production or release of Shiga-like toxins (STX) from E. coli O157:H7 in vitro. Although patients were examined for fecal STX, no STX were detected in the stools of patients treated with oral fluoroquinolones. In fact, treatment with fluoroquinolones for 5 days eradicated E. coli O157 in all patients. |
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Authors:
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M Shiomi; M Togawa; K Fujita; R Murata |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatrics international : official journal of the Japan Pediatric Society Volume: 41 ISSN: 1328-8067 ISO Abbreviation: Pediatr Int Publication Date: 1999 Apr |
Date Detail:
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Created Date: 1999-05-17 Completed Date: 1999-05-17 Revised Date: 2008-05-21 |
Medline Journal Info:
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Nlm Unique ID: 100886002 Medline TA: Pediatr Int Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 228-32 Citation Subset: IM |
Affiliation:
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Department of Pediatrics and Pediatric Emergency Medicine, Osaka City General Hospital, Japan. mshio@ka2.so-net.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Anti-Infective Agents / administration & dosage, therapeutic use* Bacterial Toxins / analysis Child Colitis / drug therapy*, etiology, microbiology Escherichia coli Infections / drug therapy*, pathology Escherichia coli O157 / pathogenicity* Female Fluoroquinolones Gastrointestinal Hemorrhage / drug therapy*, etiology, microbiology Hemolytic-Uremic Syndrome / drug therapy*, etiology, microbiology Humans Male Retrospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 0/Bacterial Toxins; 0/Fluoroquinolones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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