| Effect of early measles vaccination (AIK-C strain) for preterm infants. | |
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MedLine Citation:
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PMID: 23379893 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUNDS: Levels of maternal antibodies decrease more quickly in preterm than term infants, leaving them unprotected against measles. To protect premature infants from measles, an early vaccination trial was investigated. METHODS: Changes in the serum measles neutralization test (NT) antibody titer were examined in 152 infants (average gestational period of 29 weeks, average birth weight of 1,203 g). RESULTS: The average antibody titer (2(n) ) was 2( 3.5) at birth and 2 (2.2) at 1-3 months of age, and in all cases, NT antibody titers decreased to <1:4 (150 IU/ml). The AIK-C measles vaccine was given to 17 preterm infants at the age of 6 months, and induced sufficient serological responses without any serious adverse events. NT antibody levels did not decay during 12 months after vaccination. CONCLUSION: Early immunization at 6 months of age was effective to protect preterm infants in the outbreak setting. |
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Authors:
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T Ichikawa; A Tsuji; M Fujino; R Kusano; R Sugiyama; S Oomori; K Mori; K Maeyama; T Nakayama |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-2-4 |
Journal Detail:
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Title: Pediatrics international : official journal of the Japan Pediatric Society Volume: - ISSN: 1442-200X ISO Abbreviation: Pediatr Int Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-2-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100886002 Medline TA: Pediatr Int Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2013 The Authors. Pediatrics International © 2013 Japan Pediatric Society. |
Affiliation:
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Department of Pediatrics, Saitama Municipal Hospital Mother and Child Medical Center, Mimuro 2460, Midori-ku, Saitama city, Saitama prefecture, 336-8522, Japan. |
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