Document Detail

Effect of early measles vaccination (AIK-C strain) for preterm infants.
MedLine Citation:
PMID:  23379893     Owner:  NLM     Status:  Publisher    
BACKGROUNDS: Levels of maternal antibodies decrease more quickly in preterm than term infants, leaving them unprotected against measles. To protect premature infants from measles, an early vaccination trial was investigated. METHODS: Changes in the serum measles neutralization test (NT) antibody titer were examined in 152 infants (average gestational period of 29 weeks, average birth weight of 1,203 g). RESULTS: The average antibody titer (2(n) ) was 2( 3.5) at birth and 2 (2.2) at 1-3 months of age, and in all cases, NT antibody titers decreased to <1:4 (150 IU/ml). The AIK-C measles vaccine was given to 17 preterm infants at the age of 6 months, and induced sufficient serological responses without any serious adverse events. NT antibody levels did not decay during 12 months after vaccination. CONCLUSION: Early immunization at 6 months of age was effective to protect preterm infants in the outbreak setting.
T Ichikawa; A Tsuji; M Fujino; R Kusano; R Sugiyama; S Oomori; K Mori; K Maeyama; T Nakayama
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-4
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  -     ISSN:  1442-200X     ISO Abbreviation:  Pediatr Int     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 The Authors. Pediatrics International © 2013 Japan Pediatric Society.
Department of Pediatrics, Saitama Municipal Hospital Mother and Child Medical Center, Mimuro 2460, Midori-ku, Saitama city, Saitama prefecture, 336-8522, Japan.
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