Document Detail


Effect of early low-intensity exercise on rat hind-limb muscles following acute ischemic stroke.
MedLine Citation:
PMID:  16552944     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study examined the effects of daily low-intensity exercise following acute stroke on mass, Type I and II fiber cross-sectional area, and myofibrillar protein content of hind-limb muscles in a rat model. Adult male Sprague-Dawley rats were randomly assigned to 1 of 4 groups (n = 7-9 per group): stroke (occlusion of the right middle cerebral artery [RMCA]), control (sham RMCA procedure), exercise, and stroke-exercise. Beginning 48 hours post-stroke induction/sham operation, rats in the exercise group had 6 sessions of exercise in which they ran on a treadmill at grade 10 for 20 min/day at 10 m/min. At 8 days poststroke, all rats were anesthetized and soleus, plantaris, and gastrocnemius muscles were dissected from both the affected and unaffected sides. After 6 sessions of exercise following acute ischemic stroke, the stroke-exercise group showed the following significant (p < .05) increases compared to the stroke-only group: body weight and dietary intake, muscle weight of affected soleus and both affected and unaffected gastrocnemius muscle, Type I fiber cross-sectional area of affected soleus and both affected and unaffected gastrocnemius muscle, Type II fiber cross-sectional area of the unaffected soleus, both affected and unaffected plantaris and gastrocnemius muscle, Type II fiber distribution of affected gastrocnemius muscle, and myofibrillar protein content of both affected and unaffected soleus muscle. Daily low-intensity exercise following acute stroke attenuates hind-limb muscle atrophy in both affected and unaffected sides. The effects of exercise are more pronounced in the soleus and gastrocnemius as compared to the plantaris muscle.
Authors:
Myoung-Ae Choe; Gyeong Ju An; Yoon-Kyong Lee; Ji Hye Im; Smi Choi-Kwon; Margaret Heitkemper
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological research for nursing     Volume:  7     ISSN:  1099-8004     ISO Abbreviation:  Biol Res Nurs     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-03-23     Completed Date:  2006-04-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9815758     Medline TA:  Biol Res Nurs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  163-74     Citation Subset:  IM; N    
Affiliation:
College of Nursing, Seoul National University, Seoul, Korea. machoe@snu.ac.kr
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Animals
Body Weight
Brain Ischemia / complications*
Carotid Stenosis / complications
Disease Models, Animal
Energy Intake
Exercise Therapy / methods*
Hindlimb*
Male
Muscle Fibers, Fast-Twitch / chemistry,  pathology
Muscle Fibers, Slow-Twitch / chemistry,  pathology
Muscle Proteins / analysis
Muscle, Skeletal
Muscular Atrophy / etiology,  pathology,  prevention & control*
Myofibrils / chemistry,  pathology
Organ Size
Random Allocation
Rats
Rats, Sprague-Dawley
Stroke / complications*
Time Factors
Vasospasm, Intracranial / complications
Chemical
Reg. No./Substance:
0/Muscle Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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