Document Detail


Effect of early gestational undernutrition on angiogenic factor expression and vascularity in the bovine placentome.
MedLine Citation:
PMID:  17565057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of early gestation maternal undernutrition followed by realimentation on placentomal vascular growth and angiogenic factor expression was determined in multiparous beef cows bred to the same bull. Cows gestating only female fetuses (n = 30) were fed in equal numbers to meet the NRC requirements (control) or were fed below the NRC requirements to lose BW (nutrient restricted; NR) from d 30 to 125 of gestation. After slaughter on d 125 of gestation, 10 control and 10 NR cows were necropsied. The remaining NR cows (n = 5) were then fed to achieve a BCS equal to their control group contemporaries (n = 5) by d 220 of gestation. All cows were fed the control diet from d 220 until 250 of gestation, when the remaining control and NR cows were slaughtered and necropsied. At necropsy, placentomes were fixed via perfusion of the caruncular and cotyledonary arteries to determine capillary vascular density. Cotyledonary (fetal placental) and caruncular (maternal placental) tissues also were snap-frozen in liquid nitrogen, and mRNA concentrations of vascular endothelial growth factor and its 2 specific receptors, fms-like tyrosine kinase and kinase insert domain containing receptor, as well as placental growth factor, were determined. There was no effect of diet or day of gestation on the percentage of proliferating caruncular cells. Although diet did not impact cotyledonary cellular proliferation, there was an increase (P < 0.05) in the percentage of proliferating cells on d 250 compared with d 125 of gestation. Nutrient restriction from d 30 to 125 increased (P < or = 0.10) placental mRNA concentrations of placental growth factor and fms-like tyrosine kinase; however, there was no alteration in vascularity. By d 250 of gestation, NR cows had increased (P < 0.05) caruncular capillary surface density and decreased (P < 0.05) cotyledonary capillary area density, capillary number density, and capillary surface density compared with control cows. Although nutrient restriction had little effect on placental vascularity by d 125, upon realimentation, alterations in vascularity became apparent by d 250 of gestation, suggesting a placental programming effect.
Authors:
K A Vonnahme; M J Zhu; P P Borowicz; T W Geary; B W Hess; L P Reynolds; J S Caton; W J Means; S P Ford
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2007-06-12
Journal Detail:
Title:  Journal of animal science     Volume:  85     ISSN:  1525-3163     ISO Abbreviation:  J. Anim. Sci.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-19     Completed Date:  2007-11-09     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8003002     Medline TA:  J Anim Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2464-72     Citation Subset:  IM    
Affiliation:
Center for Nutrition and Pregnancy, North Dakota State University, Fargo 58103, USA.
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MeSH Terms
Descriptor/Qualifier:
Angiogenesis Inducing Agents / metabolism*
Animal Nutritional Physiological Phenomena*
Animals
Cattle / physiology*
Female
Food Deprivation / physiology*
Gestational Age
Maternal Nutritional Physiological Phenomena
Neovascularization, Physiologic*
Organ Size
Placenta / blood supply*
Placental Circulation
Pregnancy
Receptor Protein-Tyrosine Kinases / metabolism
Vascular Endothelial Growth Factors / metabolism
Chemical
Reg. No./Substance:
0/Angiogenesis Inducing Agents; 0/Vascular Endothelial Growth Factors; EC 2.7.10.1/Receptor Protein-Tyrosine Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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