Document Detail


Effect of early bosentan administration on the development of esophageal varices in cirrhotic rats: experimental study in Wistar rats.
MedLine Citation:
PMID:  19012044     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: This study was conducted to investigate the effect of chronic bosentan administration on the development of esophageal varices in carbon tetrachloride-induced cirrhosis in rats.
METHODS: For the development of liver cirrhosis and esophageal varices, 60 rats underwent ligation of the left adrenal vein, followed by phenobarbital and carbon tetrachloride administration. Two weeks after the beginning of carbon tetrachloride administration, rats were separated into two groups. In group I, comprising 30 rats, bosentan was continuously administered throughout the study, whereas in group II, also 30 rats, placebo instead of bosentan was continuously administered. Hemodynamic studies and morphometric analysis of the lower esophagus were performed after complete induction of cirrhosis. The total number of veins counted in the submucosa, the number of submucosal veins/mm(2) of submucosa, the total submucosal area occupied by vessels, the mean cross-sectional vessel area, the relative submucosal area (percentage) occupied by vessels, and the area of the single most-dilated submucosal vein were studied.
RESULTS: Bosentan induced a significant (P < 0.05) decrease in portal pressure, while morphometric analysis revealed a significant reduction (P < 0.05) of all parameters studied in bosentan-treated rats, except in the total and relative number of submucosal veins.
CONCLUSIONS: Bosentan administration seemed to significantly attenuate dilation of submucosal veins in the lower esophagus of cirrhotic rats. This effect was mainly attributed to a decrease in the portal pressure induced by chronic bosentan administration.
Authors:
Savas Rafailidis; Konstantinos Ballas; Kyriakos Psarras; Theodoros Pavlidis; Eleni Emoniotou; Rodoula Papamichali; Georges Kalodimos; Georges Marakis; Athanassios Sakadamis; Georges Koukoulis
Related Documents :
2124204 - Hormonal manipulation and neonatal imprinting of carbonic anhydrase isozymes in rat liver.
18395914 - Effect of oxymatrine on the tgfbeta-smad signaling pathway in rats with ccl4-induced he...
17896384 - Hepatic viscoelastic parameters measured with mr elastography: correlations with quanti...
15483424 - Prognostic value of s100b protein in carbon monoxide-poisoned rats.
8772724 - Anti-endothelial cell autoantibodies in bb rats with spontaneous and induced iddm.
21962914 - The effects of oxytocin and its analog, carbetocin, on genetic deficits in sensorimotor...
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-11-18
Journal Detail:
Title:  Journal of gastroenterology     Volume:  43     ISSN:  0944-1174     ISO Abbreviation:  J. Gastroenterol.     Publication Date:  2008  
Date Detail:
Created Date:  2008-11-17     Completed Date:  2009-02-03     Revised Date:  2013-06-18    
Medline Journal Info:
Nlm Unique ID:  9430794     Medline TA:  J Gastroenterol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  897-904     Citation Subset:  IM    
Affiliation:
Second Propedeutical Department of Surgery, Aristotle University of Thessaloniki, Hippokration General Hospital of Thessaloniki, Thessaloniki, Greece.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antihypertensive Agents / administration & dosage*
Disease Progression
Dose-Response Relationship, Drug
Drug Administration Schedule
Esophageal and Gastric Varices / etiology,  pathology,  prevention & control*
Follow-Up Studies
Liver / pathology,  physiopathology
Liver Cirrhosis, Experimental / complications*,  drug therapy,  pathology
Male
Portal Pressure / drug effects
Rats
Rats, Wistar
Sulfonamides / administration & dosage*
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Sulfonamides; Q326023R30/bosentan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Angiotensin receptor blockers are superior to angiotensin-converting enzyme inhibitors in the suppre...
Next Document:  Common coding variant in the TCF7L2 gene and study of the association with type 2 diabetes in Japane...