Document Detail

Effect of early EBV and/or CMV viremia on graft function and acute cellular rejection in pediatric liver transplantation.
MedLine Citation:
PMID:  21981027     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The clinical impact of Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infections in the early post-transplantation period are poorly documented. We investigated the prevalence and timing of EBV and CMV infections during the first 21 d post-transplantation in relation to graft function and acute cellular rejection in a large cohort of pediatric liver transplantation recipients.
PATIENTS AND METHODS: Clinical, biochemical, virological, and histopathological data of 62 consecutive children who received a liver transplant were reviewed retrospectively.
RESULTS: Seventeen patients (27%) developed EBV and 11 (18%) CMV viremia (mean interval from surgery: 7.6 d, SD 3.6 and 8.7 d, SD 6.4, respectively). EBV and CMV viremia were more common as a consequence of reactivation than of primary infection. EBV viremic recipients had more often abnormal bilirubin levels [p = 0.01; OR 5.8: 95% CI 1.3-25.5]. Acute rejection was diagnosed in 20 recipients (32.3%). No correlation was found between rejection and EBV and CMV serology before transplantation and viremia after transplantation (mean interval between the diagnosis of rejection and the detection of EBV DNA and CMV DNA: one d, SD 4.4 and five d, SD 9.2, respectively).
CONCLUSION: EBV and CMV viremia occur at a very early-stage post-transplantation and do not appear to affect the short-term outcome of the transplant.
Giuseppe Indolfi; Nigel Heaton; Melvyn Smith; Giorgina Mieli-Vergani; Mark Zuckerman
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Publication Detail:
Type:  Journal Article     Date:  2011-10-10
Journal Detail:
Title:  Clinical transplantation     Volume:  26     ISSN:  1399-0012     ISO Abbreviation:  Clin Transplant     Publication Date:    2012 Jan-Feb
Date Detail:
Created Date:  2012-02-08     Completed Date:  2012-06-12     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8710240     Medline TA:  Clin Transplant     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  E55-61     Citation Subset:  IM    
Copyright Information:
© 2011 John Wiley & Sons A/S.
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MeSH Terms
Acute Disease
Antiviral Agents / therapeutic use
Child, Preschool
Cytomegalovirus / genetics,  isolation & purification*
Cytomegalovirus Infections / diagnosis*,  drug therapy,  etiology
DNA, Viral / genetics
Epstein-Barr Virus Infections / diagnosis*,  drug therapy,  etiology
Follow-Up Studies
Ganciclovir / therapeutic use
Graft Rejection / virology*
Graft Survival
Herpesvirus 4, Human / genetics,  isolation & purification*
Liver Diseases / complications,  surgery
Liver Function Tests
Liver Transplantation / adverse effects*
Postoperative Complications*
Retrospective Studies
Viremia / diagnosis,  etiology
Grant Support
MR/J006742/1//Medical Research Council
Reg. No./Substance:
0/Antiviral Agents; 0/DNA, Viral; P9G3CKZ4P5/Ganciclovir

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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