| Effect of dual beta-blockade and calcium antagonism on endurance performance. | |
MedLine Citation:
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PMID: 2881183 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of oral clinically used doses of propranolol, atenolol, nifedipine, propranolol + nifedipine, and atenolol + nifedipine on endurance performance and ventilatory responses to graded treadmill testing was studied in 12 healthy physically active men. Maximal exercise duration was reduced by propranolol (8.5%, P less than 0.001) and its combination with nifedipine (11.1%, P less than 0.001), and to a lesser degree by atenolol (3.2%, 0.05 less than P less than 0.1), nifedipine (2.1%, P less than 0.05), and atenolol + nifedipine (3.9%, P less than 0.01). Exercise duration and heart rate (HR) and ventilatory responses to maximal exercise were equivalent with a beta-blocker and its combination with nifedipine. At submaximal exercise, beta-blockade reduced the HR and oxygen uptake, nifedipine accentuated the HR but did not alter ventilation, and all drugs modified the relative oxygen uptake corresponding to 85% of the maximal HR. Physiologic responses to submaximal exercise during combination therapy were similar to those during beta-blockade alone. This study concludes that, in physically active men, nifedipine induces a small impairment of maximal performance, but does not accentuate the reduction in effort tolerance resulting from beta-blockade. Furthermore, HR and ventilatory responses to exercise during combined beta-blockade and calcium antagonism can be predicted from those during beta-blockade alone. |
Authors:
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N F Gordon; J P van Rensburg; D P van den Heever; N B Kalliatakis; D P Myburgh |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: 19 ISSN: 0195-9131 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 1987 Feb |
Date Detail:
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Created Date: 1987-03-31 Completed Date: 1987-03-31 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1-6 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology* Adult Double-Blind Method Drug Interactions Exercise Test Heart Rate / drug effects Humans Male Nifedipine / pharmacology* Oxygen Consumption / drug effects Physical Endurance / drug effects* Physical Exertion / drug effects Random Allocation |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 21829-25-4/Nifedipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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