Document Detail

Effect of drugs on response-duration differentiation VII: response-force requirements.
MedLine Citation:
PMID:  11218227     Owner:  NLM     Status:  MEDLINE    
Rats were trained to press a lever for at least 1 s but for less than 1.3 s. The force required to press the lever was then increased or decreased by 10, 15, or 20 g. Increases in the force requirements for lever pressing decreased timing accuracy, but decreases in the force requirement had the opposite effect. Accuracy decreases at increasing force requirements were characterized by an increase in the relative frequency of responses that were too short to meet the reinforcement criterion. In contrast, increases in accuracy when the force requirements were decreased were characterized by increases in response durations that met the reinforcement criterion and decreases in the relative frequency of responses that were too short to produce the reinforcer. Phencyclidine (PCP) and methamphetamine produced dose-dependent decreases in accuracy that were associated primarily with increases in the relative frequency of short response durations, although methamphetamine also produced increases in long response durations at some doses. When the effects of PCP were determined with the force requirement increased by 10 g or decreased by 15 g, the cumulative response-duration distribution shifted toward even shorter response durations. When the effects of methamphetamine were determined with the force requirement on the lever increased by 10 g, the cumulative frequency distribution was shifted toward shorter response durations to about the same extent as it had been before force requirements increased; however, when the force required to press the lever was decreased by 15 g, these shifts toward shorter response durations almost completely disappeared. These results show that increases and decreases in the force requirements for lever pressing have different effects on the accuracy of temporal response differentiation.
G Y McClure; W C Hardwick; D E McMillan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the experimental analysis of behavior     Volume:  74     ISSN:  0022-5002     ISO Abbreviation:  J Exp Anal Behav     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-02-19     Completed Date:  2001-07-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0203727     Medline TA:  J Exp Anal Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  295-309     Citation Subset:  IM    
University of Arkansas for Medical Science, Little Rock, USA.
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MeSH Terms
Behavior, Animal / physiology*
Central Nervous System Stimulants / pharmacology*
Hallucinogens / pharmacology*
Methamphetamine / pharmacology*
Phencyclidine / pharmacology*
Rats, Sprague-Dawley
Reaction Time / drug effects
Reinforcement Schedule
Time Perception / drug effects*
Grant Support
Reg. No./Substance:
0/Central Nervous System Stimulants; 0/Hallucinogens; 537-46-2/Methamphetamine; 77-10-1/Phencyclidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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