| Effect of drugs on effective vascular compliance in acute heart failure. | |
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MedLine Citation:
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PMID: 811337 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effective vascular compliance determined by the delta V/delta P relationship was measured repeatedly in anesthetized open-chest dogs without circulatory arrest utilizing a closed circuit venous bypass system with a constant cardiac output. Production of acute heart failure by gradual aortic constriction was associated with a significant decrease in total effective vascular compliance. The effect of loading and 20-min maintenance doses of different drugs on vascular compliance of animals in acute heart failure was studied. Phenoxybenzamine (total dose 2 mg/kg) produced a rapid and sustained increase in effective vascular compliance and theophylline (12 mg/kg) produced an increase which was more gradual in development than with phenoxybenzamine. Morphine (1 mg/kg) produced a rapid but transient increase in compliance. In contrast, ethacrynic acid (100 mg) or nitroglycerin (0.6 or 1.2 mg) did not alter vascular compliance significantly. These agents differ markedly in the magnitude and time-course of effect on effective vascular compliance. |
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Authors:
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P Larochelle; R I Ogilvie |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Canadian journal of physiology and pharmacology Volume: 53 ISSN: 0008-4212 ISO Abbreviation: Can. J. Physiol. Pharmacol. Publication Date: 1975 Oct |
Date Detail:
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Created Date: 1976-03-01 Completed Date: 1976-03-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372712 Medline TA: Can J Physiol Pharmacol Country: CANADA |
Other Details:
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Languages: eng Pagination: 850-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Aorta, Thoracic / drug effects, physiopathology Coronary Vessels / drug effects, physiopathology* Dogs Ethacrynic Acid / pharmacology, therapeutic use Heart Failure / drug therapy, physiopathology* Male Morphine / pharmacology, therapeutic use Nitroglycerin / pharmacology, therapeutic use Pharmacology* Phenoxybenzamine / pharmacology, therapeutic use Theophylline / pharmacology, therapeutic use |
| Chemical | |
Reg. No./Substance:
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55-63-0/Nitroglycerin; 57-27-2/Morphine; 58-54-8/Ethacrynic Acid; 58-55-9/Theophylline; 59-96-1/Phenoxybenzamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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