Document Detail

Effect of driving pressure and nebulizer model on aerosol output during intermittent delivery with a dosimeter.
MedLine Citation:
PMID:  12006140     Owner:  NLM     Status:  MEDLINE    
Recent guidelines reinforce the need for a standardized technique during inhalational bronchoprovocation challenge testing. We investigated the effects of nebulizer model and dosimeter driving pressure on nebulizer output using a nebulized saline model. Four nebulizers (Hudson 1720, Salter 8900, Baxter Airlife, and DeVilbiss 644) were evaluated at two driving pressures (20 and 50 pounds per square inch [psi]) via a dosimeter (Salter 700) that delivered a 0.6-sec actuation. Output was determined gravimetrically after 20 actuations of saline at constant respiratory flow and volume. Output per actuation at 20 psi was 2.83 +/- 0.41 mg (mean +/- SD), 4.58 +/- 0.66, 4.75 +/- 0.42, and 4.75 +/- 1.37 for the Hudson, Salter, Baxter, and DeVilbiss, respectively, and 6.75 +/- 0.61 mg, 9.17 +/- 0.88, 9.42 +/- 1.32, and 9.83 +/- 1.75 at 50 psi. The Hudson delivered a lower volume than the other nebulizers (p < 0.0005). At 20 psi, output from the DeVilbiss had greater variability (coefficient of variation = 28.8%) compared to the Baxter (CV = 8.8%; p = 0.045). The output was greater at 50 psi than 20 psi for all models (p < 0.0005). These results demonstrate that, when choosing a nebulizer driven by a dosimeter, it is important to base that selection on published data describing aerosol output under different driving pressures.
Stephan A Alkins; Kenneth M Hurwitz; Angel Sierra
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine     Volume:  15     ISSN:  0894-2684     ISO Abbreviation:  J Aerosol Med     Publication Date:  2002  
Date Detail:
Created Date:  2002-05-13     Completed Date:  2002-06-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8809251     Medline TA:  J Aerosol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  T    
Pulmonary and Critical Care Medicine Service, Department of Internal Medicine, Walter Reed Army Medical Center, Washington, DC, USA.
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MeSH Terms
Bronchial Provocation Tests / instrumentation*,  standards
Equipment Design
Nebulizers and Vaporizers / standards*
Prospective Studies
Sodium Chloride / administration & dosage
Weights and Measures
Reg. No./Substance:
0/Aerosols; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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