Document Detail

Effect of dorzolamide and latanoprost on intraocular pressure after small incision cataract surgery.
MedLine Citation:
PMID:  10609207     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the effect of dorzolamide 2% and latanoprost 0.005% on intraocular pressure (IOP) after small incision cataract surgery. SETTING: Department of Ophthalmology, University of Vienna, Vienna, Austria. METHODS: This prospective study comprised 102 eyes of 102 consecutive patients scheduled for small incision cataract surgery. The patients were assigned preoperatively to 1 of 3 groups of 34 each: dorzolamide, latanoprost, and control (no treatment). One drop of the assigned medication was instilled immediately after surgery. Intraocular pressure was measured preoperatively and 6 and 20 to 24 hours postoperatively. RESULTS: Six hours after surgery, the mean increase in IOP was 1.9 mm Hg +/- 3.9 (SD) in the dorzolamide group (P = .004 versus control), 2.2 +/- 3.0 mm Hg in the latanoprost group (P = .005 versus control), and 4.8 +/- 5.2 mm Hg in the control group. Twenty to 24 hours postoperatively, IOP decreased a mean of -0.9 +/- 3.5 mm Hg in the dorzolamide group (P = .012 versus control) and increased a mean of 0.3 +/- 3.6 mm Hg in the latanoprost group (P = 0.24 versus control) and 1.3 +/- 4.2 mm Hg in the control group. One eye in the dorzolamide group, 1 eye in the latanoprost group, and 4 eyes in the control group had an IOP of 30 mm Hg or higher 6 hours postoperatively. CONCLUSION: Six hours postoperatively, dorzolamide and latanoprost were effective in reducing the IOP increase after small incision cataract surgery; however, at 20 to 24 hours, only dorzolamide was effective. Neither drug prevented IOP spikes of 30 mm Hg or higher.
G Rainer; R Menapace; K Schmetterer; O Findl; M Georgopoulos; C Vass
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of cataract and refractive surgery     Volume:  25     ISSN:  0886-3350     ISO Abbreviation:  J Cataract Refract Surg     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-01-24     Completed Date:  2000-01-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8604171     Medline TA:  J Cataract Refract Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1624-9     Citation Subset:  IM    
Department of Ophthalmology, University of Vienna, Austria.
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MeSH Terms
Carbonic Anhydrase Inhibitors / administration & dosage,  therapeutic use*
Cataract Extraction* / adverse effects
Drug Therapy, Combination
Intraocular Pressure / drug effects*
Lens Implantation, Intraocular
Ocular Hypertension / etiology,  prevention & control
Ophthalmic Solutions / administration & dosage,  therapeutic use
Prospective Studies
Prostaglandins F, Synthetic / administration & dosage,  therapeutic use*
Sulfonamides / administration & dosage,  therapeutic use*
Surgical Procedures, Minimally Invasive
Thiophenes / administration & dosage,  therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Carbonic Anhydrase Inhibitors; 0/Ophthalmic Solutions; 0/Prostaglandins F, Synthetic; 0/Sulfonamides; 0/Thiophenes; 130209-82-4/latanoprost; 130693-82-2/dorzolamide

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