Document Detail


Effect of the dopamine D3 receptor antagonist GSK598809 on brain responses to rewarding food images in overweight and obese binge eaters.
MedLine Citation:
PMID:  22445776     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The dopamine D(3) receptor is thought to be a potential target for treating compulsive disorders such as drug addiction and obesity. Here, we used functional Magnetic Resonance Imaging (fMRI) to investigate the effects the selective dopamine D(3) receptor antagonist GSK598809 on brain activation to food images in a sample of overweight and obese binge-eating subjects. Consistent with previous studies, processing of food images was associated with activation of a network of reward areas including the amygdala, striatum and insula. However, brain activation to food images was not modulated by GSK598809. The results demonstrate that D(3) receptor manipulation does not modulate brain responses to food images in overweight and obese subjects.
Authors:
Chris M Dodds; Barry O'Neill; John Beaver; Aidan Makwana; Massimo Bani; Emilio Merlo-Pich; Paul C Fletcher; Annelize Koch; Edward T Bullmore; Pradeep J Nathan
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2012-03-21
Journal Detail:
Title:  Appetite     Volume:  59     ISSN:  1095-8304     ISO Abbreviation:  Appetite     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-06-04     Completed Date:  2012-09-27     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  8006808     Medline TA:  Appetite     Country:  England    
Other Details:
Languages:  eng     Pagination:  27-33     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Amygdala / drug effects*,  physiology
Binge-Eating Disorder / metabolism,  physiopathology*
Cerebral Cortex / drug effects*,  physiology
Corpus Striatum / drug effects*,  physiology
Cross-Over Studies
Double-Blind Method
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Obesity / physiopathology
Overweight / physiopathology
Receptors, Dopamine D3 / antagonists & inhibitors*
Reward
Young Adult
Grant Support
ID/Acronym/Agency:
093270//Wellcome Trust; 095692//Wellcome Trust
Chemical
Reg. No./Substance:
0/Receptors, Dopamine D3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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