Document Detail


Effect of domestic cooking on human bioavailability of naringenin, chlorogenic acid, lycopene and beta-carotene in cherry tomatoes.
MedLine Citation:
PMID:  15309458     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Epidemiological data showed that tomato and tomato product (sauce, paste) consumption is associated with a protective effect against the development of some chronic-degenerative diseases. Tomato antioxidant bioactive molecules such as carotenoids and polyphenols could be responsible, at least in part, for the healthy effect observed. The bioavailability of these compounds is an essential requirement to sustain their in vivo role. While it is well known that many factors can influence the bioaccessibility of carotenoids from the food matrix, there is little information about the factors affecting phenolic compounds' bioaccessibility. AIM OF THE STUDY: This investigation was carried out to evaluate the effect of domestic cooking on the bioavailability in humans of antioxidant molecules after the administration of a test meal containing cherry tomatoes. METHODS: A cross-over design was conducted. Subjects (3 females and 2 males) consumed experimental meals containing fresh and cooked cherry tomatoes. Blood collection was performed at different time intervals (0, 2, 4, 6, 8 and 24 h). RESULTS: Carotenoid and phenol plasma concentrations were measured. Plasma levels of lycopene and beta-carotene were not significantly different with respect to the baseline after ingestion of both the test meals, while plasma concentrations of naringenin and chlorogenic acid increased significantly with respect to the baseline (P<0.05) after administration of cooked cherry tomatoes, but not after administration of fresh cherry tomatoes. CONCLUSIONS: The present study indicated that domestically cooked tomatoes significantly increase naringenin and chlorogenic acid plasma levels. Considering that both naringenin and chlorogenic acid are widely studied for their potential healthy properties, evidence of their bioavailability and of the factors influencing their bioaccessibility is an important tool to sustain the possibility that these polyphenols play a biological role in human physiology.
Authors:
R Bugianesi; M Salucci; C Leonardi; R Ferracane; G Catasta; E Azzini; G Maiani
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-04-05
Journal Detail:
Title:  European journal of nutrition     Volume:  43     ISSN:  1436-6207     ISO Abbreviation:  Eur J Nutr     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-14     Completed Date:  2005-04-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100888704     Medline TA:  Eur J Nutr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  360-6     Citation Subset:  IM    
Affiliation:
Antioxidant Research Laboratory, Unit of Human Nutrition, National Institute for Food and Nutrition Research (INRAN), Via Ardeatina 546, 00178 Rome, Italy. bugianesi@inran.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Antioxidants / metabolism,  pharmacokinetics
Area Under Curve
Biological Availability
Carotenoids / blood,  pharmacokinetics*
Chlorogenic Acid / blood,  pharmacokinetics*
Cookery / methods*
Cross-Over Studies
Female
Flavanones / blood,  pharmacokinetics*
Humans
Intestinal Absorption
Lycopersicon esculentum / chemistry*
Male
beta Carotene / blood,  pharmacokinetics*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Flavanones; 327-97-9/Chlorogenic Acid; 36-88-4/Carotenoids; 480-41-1/naringenin; 502-65-8/lycopene; 7235-40-7/beta Carotene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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