Document Detail

Effect of docosahexaenoic acid content of maternal diet on auditory brainstem conduction times in rat pups.
MedLine Citation:
PMID:  11111168     Owner:  NLM     Status:  MEDLINE    
Previous studies of dietary docosahexaenoic acid (DHA; 22:6n-3) effects on neurodevelopment have focused mainly on effects on the visual system; these studies may be confounded by effects on the retina rather than on neural pathways. Auditory brainstem conduction times (ABCTs) provide an alternate measure of central neural development. We conducted a dose-response study in which ABCTs were measured in pups whose dams were fed diets containing one of three levels of DHA (2, 4 or 6% of total fatty acids) from a single cell oil. Diets were fed during pregnancy and lactation, and pups were randomly cross-fostered on postnatal day 3 to minimize litter effects. ABCTs showed a dose-response effect, with higher levels of dietary DHA being associated with longer conduction times on postnatal day 31 (p < 0.05). Higher dietary DHA was reflected in pup cerebrums collected on postnatal days 3 and 31, and levels of arachidonic acid (AA, 20:4n-6) were inversely related to levels of DHA. This study demonstrated that the auditory brainstem response is sensitive for identifying effects of diet on neurodevelopment, and that supplementing the maternal diet with high levels of DHA may negatively impact development of the central auditory system of offspring.
J E Stockard; M D Saste; V J Benford; L Barness; N Auestad; J D Carver
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Developmental neuroscience     Volume:  22     ISSN:  0378-5866     ISO Abbreviation:  Dev. Neurosci.     Publication Date:    2000 Sep-Dec
Date Detail:
Created Date:  2001-02-01     Completed Date:  2001-02-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7809375     Medline TA:  Dev Neurosci     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  494-9     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel
Division of Infectious Disease, Department of Pediatrics, University of South Florida College of Medicine, Tampa, FL 33606, USA.
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MeSH Terms
Cholesterol / analysis
Docosahexaenoic Acids / administration & dosage*
Dose-Response Relationship, Drug
Evoked Potentials, Auditory, Brain Stem / drug effects*
Fatty Acids / analysis
Food, Formulated*
Milk / chemistry
Phospholipids / chemistry
Phosphorus / analysis
Prenatal Exposure Delayed Effects*
Proteins / analysis
Rats, Sprague-Dawley
Reaction Time / drug effects
Telencephalon / chemistry
Reg. No./Substance:
0/Fatty Acids; 0/Phospholipids; 0/Proteins; 25167-62-8/Docosahexaenoic Acids; 57-88-5/Cholesterol; 7723-14-0/Phosphorus

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