Document Detail

Effect of dobutamine on left ventricular functional geometry after acute myocardial infarction: experimental study.
MedLine Citation:
PMID:  17489344     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Acute myocardial infarction causes left ventricular (LV) remodelling, which forms the substrate for its early and late complications. The aim of this experimental study was to evaluate the acute changes in LV functional geometry after acute myocardial infarction using echocardiography and to investigate the effect of continuous intravenous dobutamine administration on those changes. METHODS: In 22 pigs acute myocardial infarction was induced by ligation of the anterior descending branch of the left coronary artery. In 11 animals dobutamine was administered at a rate of 5 microg/kg/min (Group B), while the remainder (Group A) served as controls. Before infarction and 5, 15, 45 and 75 minutes after, the fractional shortening of the long (FSL) and short (FSS) axes of the LV were measured echocardiographically and the ejection fraction (EF) was calculated. RESULTS: In Group A FSL and EF reduced significantly after infarction (p < 0.0001), while FSS increased significantly (p < 0.05). In Group B FSL and EF reduced significantly 5 minutes after infarction and then returned progressively to normal values after 15 min (EF) and 45 min (FSL). FSS did not change significantly during 75 minutes after infarction. CONCLUSIONS: Dobutamine, administered at a rate of 5 microg/kg/min during acute experimental anterior myocardial infarction, before the appearance of early complications, may prevent the acute, unfavourable remodelling of the LV, as manifested by a decrease in FSL and EF and a compensatory increase in FSS.
Nikolaos S Saridakis; Savvas T Toumanidis; Anastasia M Vintzileou; Nikolaos Tsirikos; Demetrios Haniotis; Georgios Kottis; Anna Kalantaridou; Stamatios F Stamatelopoulos; Spyridon D Moulopoulos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hellenic journal of cardiology : HJC = Hellēnikē kardiologikē epitheōrēsē     Volume:  48     ISSN:  1109-9666     ISO Abbreviation:  -     Publication Date:    2007 Mar-Apr
Date Detail:
Created Date:  2007-05-10     Completed Date:  2007-08-24     Revised Date:  2009-02-12    
Medline Journal Info:
Nlm Unique ID:  101257381     Medline TA:  Hellenic J Cardiol     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  72-9     Citation Subset:  IM    
Department of Clinical Therapeutics, Athens University Medical School, "Alexandra" Hospital, Athens, Greece.
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MeSH Terms
Adrenergic beta-Agonists / pharmacology*
Analysis of Variance
Cardiotonic Agents / pharmacology*
Coronary Vessels / physiopathology,  surgery
Disease Models, Animal
Dobutamine / pharmacology*
Image Processing, Computer-Assisted
Infusions, Intravenous
Ligation / adverse effects
Myocardial Contraction / drug effects
Myocardial Infarction / drug therapy*,  physiopathology*,  ultrasonography
Research Design
Stroke Volume / drug effects
Time Factors
Vascular Resistance / drug effects
Ventricular Function, Left / drug effects*
Ventricular Remodeling / drug effects
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Cardiotonic Agents; 34368-04-2/Dobutamine
Erratum In:
Hellenic J Cardiol. 2007 Sep-Oct;48(5):319
Note: Haniotis, Demetrios [added]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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