| Effect of diuretics, channel modulators and signal interceptors on contractility of the trabecular meshwork. | |
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MedLine Citation:
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PMID: 9176896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Measurements of isometric tension were performed on isolated trabecular meshwork (TM) and ciliary muscle (CM) strips of the bovine eye. Anterior segments of bovine eyes with well-preserved TM were perfused to measure outflow rate. (1) Bumetanide (10(-4) mol/l) and hydrochlorothiazide (10(-4) mol/l) did not change the contractility of TM and CM strips in the presence or absence of carbachol. Ethacrynic acid dose-dependently relaxed TM and CM strips precontracted either by carbachol or endothelin. (2) Cytochalasin D totally relaxed TM and CM strips precontracted by carbachol. The outflow rate almost doubled after application of cytochalasin D. (3) The effects of various modulators of K+ and Ca2+ channels are summarized. Carbachol and endothelin are postulated to modify nonselective cation channels. An effective blocker of nonselective cation channels (flufenamic acid) relaxed TM and CM precontracted by carbachol or endothelin. These relaxing effects were independent of the relaxing effects of ethacrynic acid and isosorbide dinitrate. (4) Evidence for the presence of various transporters and receptors in TM cells is summarized. (5) The TM per se is a contractile element which is involved in the regulation of aqueous humor outflow. The contractility of TM and CM cells is differently modulated. |
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Authors:
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M Wiederholt; N Dörschner; J Groth |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde Volume: 211 ISSN: 0030-3755 ISO Abbreviation: Ophthalmologica Publication Date: 1997 |
Date Detail:
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Created Date: 1997-08-11 Completed Date: 1997-08-11 Revised Date: 2007-09-17 |
Medline Journal Info:
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Nlm Unique ID: 0054655 Medline TA: Ophthalmologica Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 153-60 Citation Subset: IM |
Affiliation:
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Institut für Klinische Physiologie, Universitätsklinikun Benjamin Franklin, Freie Universität Berlin, Germany. wiederho@zedat.fu-berlin.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Animals Anterior Eye Segment / cytology, drug effects, physiology Aqueous Humor / physiology Bumetanide / pharmacology Carbachol / pharmacology Cattle Cells, Cultured Ciliary Body / cytology, drug effects, physiology Cytochalasin D / pharmacology Diuretics / pharmacology* Ethacrynic Acid / pharmacology Hydrochlorothiazide / pharmacology Ion Channels / drug effects, physiology* Isometric Contraction / drug effects* Muscle, Smooth / cytology, drug effects, metabolism Parasympathomimetics / pharmacology* Patch-Clamp Techniques Perfusion Signal Transduction / drug effects* Trabecular Meshwork / cytology, drug effects, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Diuretics; 0/Ion Channels; 0/Parasympathomimetics; 22144-77-0/Cytochalasin D; 28395-03-1/Bumetanide; 51-83-2/Carbachol; 58-54-8/Ethacrynic Acid; 58-93-5/Hydrochlorothiazide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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