| Effect of disulfiram pretreatment on the tissue distribution, macromolecular binding, and excretion of [U-1,2-14C]dichloroethane in the rat. | |
| | |
MedLine Citation:
|
PMID: 2868868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effect of disulfiram (DSF) pretreatment on the distribution of [14C]ethylene dichloride (EDC) in selected organs and/or tissues of control and EDC-pretreated rats was studied. The presence of EDC metabolites and their binding to an acid-insoluble extract of the tissues, as well as purified protein and DNA, were evaluated. Dietary DSF was found to modulate the distribution, excretion, and macromolecular binding of EDC and/or its metabolites at 4 and 24 hr following ip administration. The urinary excretion of [14C]EDC metabolites was not affected by subchronic inhalation exposure to nonradiolabeled EDC. However, DSF pretreatment increased the fat deposition of EDC and decreased the urinary excretion of its metabolites. DSF also increased the binding of EDC metabolites to DNA and decreased the binding to protein in the liver, kidneys, spleen, and testes. However, prior exposure to EDC alone increased the binding of its metabolites to DNA in the kidneys only. |
| | |
Authors:
|
O J Igwe; S S Que Hee; W D Wagner |
Related Documents
:
|
2764708 - In vitro covalent binding of the pyrethroids cismethrin, cypermethrin and deltamethrin ... 22667988 - Bipartite tetracysteine display reveals allosteric control of ligand-specific egfr acti... 23192178 - Tdp-43 toxicity and the usefulness of junk. 9337868 - Binding of glutathione and an inhibitor to microsomal glutathione transferase. 8604098 - Light and electron microscopic study of a myxosporean, tetrauronema desaequalis n. sp. ... 16249178 - Cooperative actions of tra2alpha with 9g8 and srp30c in the rna splicing of the gonadot... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Drug metabolism and disposition: the biological fate of chemicals Volume: 14 ISSN: 0090-9556 ISO Abbreviation: Drug Metab. Dispos. Publication Date: 1986 Jan-Feb |
Date Detail:
|
Created Date: 1986-04-21 Completed Date: 1986-04-21 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 9421550 Medline TA: Drug Metab Dispos Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 65-72 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Carbon Radioisotopes / diagnostic use DNA / metabolism* Disulfiram / pharmacology* Ethylene Dichlorides / metabolism*, toxicity Glutathione Transferase / biosynthesis Hydrocarbons, Chlorinated / metabolism* Kidney / metabolism Lung / metabolism Male Neoplasms / chemically induced Protein Binding Rats Tissue Distribution |
| Chemical | |
Reg. No./Substance:
|
0/Carbon Radioisotopes; 0/Ethylene Dichlorides; 0/Hydrocarbons, Chlorinated; 107-06-2/ethylene dichloride; 9007-49-2/DNA; 97-77-8/Disulfiram; EC 2.5.1.18/Glutathione Transferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The disposition and metabolic fate of 14C-cibenzoline in man.
Next Document: The effects of cyclosporin A (CsA) on hepatic microsomal drug metabolism in the rat.