| Effect of disability level on response to pulmonary rehabilitation in patients with idiopathic pulmonary fibrosis. | |
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MedLine Citation:
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PMID: 21810145 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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SUMMARY AT A GLANCE: Responses to pulmonary rehabilitation were investigated in IPF patients, who were grouped according to the Medical Research Council (MRC) dyspnoea scale. Compared to those with severe disability (MRC grade 4 or 5 dyspnoea), who received little or no benefit from rehabilitation, there were greater benefits for subjects with MRC grade 2 or 3 dyspnoea. ABSTRACT: Background and objective: It is unclear whether the severity of functional limitation resulting from IPF affects the response to pulmonary rehabilitation. The aim of this study was to compare the outcomes of rehabilitation in patients with IPF, who were grouped according to the Medical Research Council (MRC) dyspnoea scale. Methods: Sixty-five subjects (46.71% males) with stable IPF were enrolled in an 8-week pulmonary rehabilitation program. Subjects with MRC grades 2, 3 and 4 dyspnoea undertook a supervised out-patient program, whereas subjects with MRC grade 5 dyspnoea participated in an unsupervised, home-based program, with review every two weeks. The outcome measures included functional exercise capacity (6MWD), health status (SF-36), and dyspnoea (transition dyspnoea index, TDI), which were measured at baseline and immediately after the program. Hospitalizations for respiratory exacerbations were compared for the 12 months preceding and following the program. Results: The number of subjects with MRC grades 2, 3, 4 and 5 dyspnoea were 16 (25%), 17 (26%), 17 (26%) and 15 (23%), respectively. There were differences between these groups in the magnitude of change in 6MWD, SF-36 and TDI (all P < 0.05). Specifically, subjects with MRC grade 2 or 3 dyspnoea demonstrated clinically and statistically significant improvements in 6MWD and SF-36 following rehabilitation (all P < 0.05). In contrast, for all measures, subjects with MRC grade 4 or 5 dyspnoea showed little or no improvement, or deteriorated following rehabilitation. Hospitalizations were reduced following rehabilitation only in subjects with MRC grade 2, 3 or 4 dyspnoea (P < 0.05). Conclusions: The response to pulmonary rehabilitation in subjects with IPF varies depending on the MRC grade of dyspnoea, with little benefit being observed in subjects with severe functional limitation. |
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Authors:
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Ryo Kozu; Sue Jenkins; Hideaki Senjyu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-2 |
Journal Detail:
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Title: Respirology (Carlton, Vic.) Volume: - ISSN: 1440-1843 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9616368 Medline TA: Respirology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Authors. Respirology © 2011 Asian Pacific Society of Respirology. |
Affiliation:
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Department of Rehabilitation Medicine, Nagasaki University Hospital, Nagasaki, and Department of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, Physiotherapy Department, Sir Charles Gairdner Hospital, Perth, School of Physiotherapy and Curtin Health Innovation Research Institute, Curtin University, Perth, Lung Institute of Western Australia and Centre for Asthma, Allergy and Respiratory Research, The University of Western Australia, Perth, Australia. |
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