| Effect of dipyridamole during acute stroke: exploring antithrombosis and neuroprotective benefits. | |
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MedLine Citation:
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PMID: 20955428 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Currently, many stroke-prone individuals take antithrombotic drugs, which have known antiplatelet properties, to decrease stroke incidence. There is now evidence that this regimen could also reduce stroke severity through neuroprotective, nonplatelet mechanisms that include anti-inflammatory processes. Inflammation was found to play an important role in atherosclerosis/thrombosis development and acute stroke progression. In light of these findings, prevention strategies that target inflammatory mediators are under investigation. A common secondary stroke prevention therapeutic, dipyridamole, has shown promise for reducing stroke recurrence without increasing bleeding. In addition to its antiplatelet ability, dipyridamole has positive effects on vascular endothelium and inflammation. This review explores the effect of dipyridamole during acute stroke, revealing its potential use for improving poststroke clinical outcome. |
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Authors:
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C D d'Esterre; T-Y Lee |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1207 ISSN: 1749-6632 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-19 Completed Date: 2010-11-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 71-5 Citation Subset: IM |
Copyright Information:
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© 2010 New York Academy of Sciences. |
Affiliation:
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Department of Medical Biophysics, The University of Western Ontario, London, Ontario, Canada. cdesterr@uwo.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cerebrovascular Circulation / drug effects Dipyridamole / therapeutic use* Disease Models, Animal Fibrinolytic Agents / therapeutic use Humans Infarction, Middle Cerebral Artery / drug therapy, physiopathology Neuroprotective Agents / therapeutic use Platelet Aggregation Inhibitors / therapeutic use Rabbits Recurrence Stroke / drug therapy*, physiopathology, prevention & control |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents; 0/Neuroprotective Agents; 0/Platelet Aggregation Inhibitors; 58-32-2/Dipyridamole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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