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THE EFFECT OF DIPHTHERIA TOXIN ON THE METABOLISM OF HELA CELLS : II. EFFECT ON NUCLEIC ACID METABOLISM.
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MedLine Citation:
PMID:  19867174     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The effect of toxin on the incorporation of uridine and thymidine into nucleic acids was investigated. P(32) orthophosphate incorporation into the nucleoside phosphate fraction was also investigated. No early effect of toxin on nucleic acid synthesis was evident and only a slight effect of toxin on nucleoside phosphate formation was found prior to 1.5 hours after toxin addition. Both these processes, however, were found to be sensitive to dinitrophenol. These results are interpreted as indicating that toxin does not act by a general uncoupling of oxidation from phosphorylation. Other possible mechanisms of toxin action are proposed.
Authors:
N Strauss
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  112     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1960 Aug 
Date Detail:
Created Date:  2010-06-22     Completed Date:  2010-06-22     Revised Date:  2010-09-28    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  351-9     Citation Subset:  -    
Affiliation:
Department of Microbiology, Yale University, New Haven.
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Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Copyright © Copyright, 1960, by The Rockefeller Institute
Received Day: 20 Month: 4 Year: 1960
Print publication date: Day: 1 Month: 8 Year: 1960
Volume: 112 Issue: 2
First Page: 351 Last Page: 359
ID: 2137219
PubMed Id: 19867174

THE EFFECT OF DIPHTHERIA TOXIN ON THE METABOLISM OF HELA CELLS : II. EFFECT ON NUCLEIC ACID METABOLISM
Norman Strauss
From the Department of Microbiology, Yale University, New Haven


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